Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding
文献类型：期刊论文
| 作者 | Du H; Deng W; Aimone JB; Ge M; Parylak S; Walch K; Zhang W; Cook J; Song H; Wang L |
| 刊名 | Proceedings of the National Academy of Sciences of the United States of America
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| 出版日期 | 2016 |
| 英文摘要 | Rewarding experiences are often well remembered, and such memory formation is known to be dependent on dopamine modulation of the neural substrates engaged in learning and memory; however, it is unknown how and where in the brain dopamine signals bias episodic memory toward preceding rather than subsequent events. Here we found that photostimulation of channelrhodopsin-2-expressing dopaminergic fibers in the dentate gyrus induced a long-term depression of cortical inputs, diminished theta oscillations, and impaired subsequent contextual learning. Computational modeling based on this dopamine modulation indicated an asymmetric association of events occurring before and after reward in memory tasks. In subsequent behavioral experiments, preexposure to a natural reward suppressed hippocampus-dependent memory formation, with an effective time window consistent with the duration of dopamine-induced changes of dentate activity. Overall, our results suggest a mechanism by which dopamine enables the hippocampus to encode memory with reduced interference from subsequent experience. |
| 收录类别 | SCI |
| 原文出处 | http://www.pnas.org/content/113/37/E5501.long |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/9789]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 作者单位 | Proceedings of the National Academy of Sciences of the United States of America |
| 推荐引用方式 GB/T 7714 | Du H,Deng W,Aimone JB,et al. Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding[J]. Proceedings of the National Academy of Sciences of the United States of America,2016. |
| APA | Du H.,Deng W.,Aimone JB.,Ge M.,Parylak S.,...&Mu Y.(2016).Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding.Proceedings of the National Academy of Sciences of the United States of America. |
| MLA | Du H,et al."Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding".Proceedings of the National Academy of Sciences of the United States of America (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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