Escherichia coli outer membrane protease OmpT confers resistance to urinary cationic peptides
文献类型：期刊论文
| 作者 | Changye Hui; Yan Guo; Qiushan He; Liang Peng; Shuchi Wu; Hong Cao; Shenghe Huang |
| 刊名 | MICROBIOLOGY AND IMMUNOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 54期号:8页码:452-459 |
| 英文摘要 | Escherichia coli OmpT, located in the outer membrane, has been characterized as a plasminogen activator, with the ability to hydrolyze protamine and block its entry. In this investigation, a complex of low molecular weight cationic peptides purified from human urine by a combination of membraneultrafiltration and weak cation exchange chromatography was characterized. The impact of OmpT on E. coli resistance to urinary cationic peptides was investigated by testing ompT knockout strains. The ompT mutants were more susceptible to urinary cationic peptides than ompT+ strains, and this difference was abolished by complementation of the mutants with pUC19 carrying the ompT gene. The urinary protease inhibitor ulinastatin greatly decreased the resistance of the ompT+ strains. Overall, the data indicate that OmpT may help E. coli persist longer in the urinary tract by enabling it toresist the antimicrobial activity of urinary cationic peptides. |
| 收录类别 | SCI |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pubmed/20646209 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/3147]  |
| 专题 | 深圳先进技术研究院_其他 |
| 作者单位 | MICROBIOLOGY AND IMMUNOLOGY |
| 推荐引用方式 GB/T 7714 | Changye Hui,Yan Guo,Qiushan He,et al. Escherichia coli outer membrane protease OmpT confers resistance to urinary cationic peptides[J]. MICROBIOLOGY AND IMMUNOLOGY,2010,54(8):452-459. |
| APA | Changye Hui.,Yan Guo.,Qiushan He.,Liang Peng.,Shuchi Wu.,...&Shenghe Huang.(2010).Escherichia coli outer membrane protease OmpT confers resistance to urinary cationic peptides.MICROBIOLOGY AND IMMUNOLOGY,54(8),452-459. |
| MLA | Changye Hui,et al."Escherichia coli outer membrane protease OmpT confers resistance to urinary cationic peptides".MICROBIOLOGY AND IMMUNOLOGY 54.8(2010):452-459. |
入库方式： OAI收割
来源：深圳先进技术研究院
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