Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury
文献类型：期刊论文
| 作者 | J Xiao; EC Liong; YP Ching; RCC Chang; ML Fung; AM Xu; KF So; GL Tipoe |
| 刊名 | NUTRITION & DIABETES
 |
| 出版日期 | 2013 |
| 英文摘要 | Background:Lycium barbarum polysaccharides (LBPs) are antioxidant and neuroprotective derivative from Wolfberry. However, whether LBP has a protective effect in non-alcoholic steatohepatitis (NASH)-induced hepatic injury is still unknown. Objective:We aimed to study the possible hepatoprotective effects and mechanisms of LBP on a diet-induced NASH rat model. Methods and Design:In this study, female rats were fed a high-fat diet to induce NASH with or without an oral 1 mg kg−1 LBP feeding daily for 8 weeks. After 8 weeks, blood serum and liver samples from each rat were subjected to histological analysis, biochemical and molecular measurements. Results:Compared with control rats, NASH rats showed typical NASH features including an increase in liver injury, lipid content, fibrosis, oxidative stress, inflammation and apoptosis. In contrast, NASH+LBP-co-treated rats showed (1) improved histology and free fatty acid levels; (2) re-balance of lipid metabolism; (3) reduction in profibrogenic factors through the TGF-β/SMAD pathway; (4) improved oxidative stress through cytochrome P450 2E1-dependent pathway; (5) reduction in hepatic pro-inflammatory mediators and chemokines production; and (6) amelioration of hepatic apoptosis through the p53-dependent intrinsic and extrinsic pathways. The preventive effects of LBP were partly modulated through the PI3K/Akt/FoxO1, LKB1/AMPK, JNK/c-Jun and MEK/ERK pathways and the downregulation of transcription factors in the liver, such as nuclear factor-κB and activator protein-1. Conclusion:LBP is a novel hepatoprotective agent against NASH caused by abnormal liver metabolic functions. |
| 收录类别 | SCI |
| 原文出处 | http://www.nature.com/nutd/journal/v3/n7/full/nutd201322a.html |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5231]  |
| 专题 | 深圳先进技术研究院_其他 |
| 作者单位 | NUTRITION & DIABETES |
| 推荐引用方式 GB/T 7714 | J Xiao,EC Liong,YP Ching,et al. Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury[J]. NUTRITION & DIABETES,2013. |
| APA | J Xiao.,EC Liong.,YP Ching.,RCC Chang.,ML Fung.,...&GL Tipoe.(2013).Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury.NUTRITION & DIABETES. |
| MLA | J Xiao,et al."Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury".NUTRITION & DIABETES (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。