Application of strontium doped calcium polyphosphate bioceramic as scaffolds for bone tissue engineering
文献类型：期刊论文
| 作者 | Xie Huixu; Wang Jianyun; Li Chuansong; Gu Zhipeng; Chen Qianming; Li Longjiang |
| 刊名 | CERAMICS INTERNATIONAL
 |
| 出版日期 | 2013 |
| 英文摘要 | The critical success factors for bone tissue engineering in clinical applications are scaffolds. Ion doping is one of the most important methods to modify the properties of bioceramics for better angiogenesis abilities, biomechanical properties, and biocompatibility. This paper presents a novel ion doping method applied in calcium polyphosphate (CPP)-based bioceramic scaffolds substituted by strontium ions to form (SCPP) scaffolds for bone tissue regeneration. The microstructure and crystallization of the scaffolds were detected by scanning electron microscopy (SEM) and X-ray diffraction (XRD). Degradation tests were assessed to evaluate the mechanical and chemical stabilities of SCPP in vitro. The cell biocompatibility was measured with respect to the cytotoxicity of the extractions of scaffolds. Bone implantation was performed to evaluate the biodegradability and osteoconductivity of the scaffolds, and the bone formation examined by using X-ray radiography. The results indicated that the obtained SCPP scaffolds had a single CPP phase. The SCPP scaffolds yielded a better degradation property than the pure CPP scaffold. The MTT assay and in vivo results reveal that the SCPP scaffolds exhibited a better cell biocompatibility and tissue biocompatibility than CPP and hydroxyapatite (HA) scaffolds. The in vivo immunohistochemistry staining for VEGF also showed that SCPP had a potential to promote the formation of angiogenesis and the regeneration of bone. SCPP scaffold could serve as a potential biomaterial with stimulating angiogenesis in bone tissue engineering and bone repair. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0272884213004926# |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5234]  |
| 专题 | 深圳先进技术研究院_其他 |
| 作者单位 | CERAMICS INTERNATIONAL |
| 推荐引用方式 GB/T 7714 | Xie Huixu,Wang Jianyun,Li Chuansong,et al. Application of strontium doped calcium polyphosphate bioceramic as scaffolds for bone tissue engineering[J]. CERAMICS INTERNATIONAL,2013. |
| APA | Xie Huixu,Wang Jianyun,Li Chuansong,Gu Zhipeng,Chen Qianming,&Li Longjiang.(2013).Application of strontium doped calcium polyphosphate bioceramic as scaffolds for bone tissue engineering.CERAMICS INTERNATIONAL. |
| MLA | Xie Huixu,et al."Application of strontium doped calcium polyphosphate bioceramic as scaffolds for bone tissue engineering".CERAMICS INTERNATIONAL (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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