Incremental value of global systolic dyssynchrony in determining the occurrence of functional mitral regurgitation in patients with left ventricular systolic dysfunction
文献类型：期刊论文
| 作者 | Liang Yu-Jia; Zhang Qing; Fang Fang; Lee Alex Pui-Wai; Liu Ming; Yan Bryan Ping-Yen; Lam Yat-Yin; Chan Gary Chin-Pang; Yu Cheuk-Man |
| 刊名 | EUROPEAN HEART JOURNAL
 |
| 出版日期 | 2013 |
| 英文摘要 | Aims The aim of this study was to assess the contribution of left ventricular (LV) systolic dyssynchrony to functional mitral regurgitation (MR). Methods and results Patients (n = 136) with LV systolic dysfunction (ejection fraction <50%) and at least mild MR were prospectively recruited. The effective regurgitant orifice area (EROA) was assessed by the proximal isovelocity surface area method. Left ventricular global systolic dyssynchrony [the maximal difference in time to peak systolic velocity among the 12 LV segments (Ts-Dif)] and regional systolic dyssynchrony (the delay between the anterolateral and posteromedial papillary muscle attaching sites) were assessed by tissue Doppler imaging. Left ventricular global and regional remodelling, systolic function, indices of mitral valvular and annular deformation were also measured. The size of the EROA correlated with the degrees of mitral deformation, LV remodelling, systolic function, and systolic dyssynchrony. By multivariate logistic regression analysis, the mitral valve tenting area (OR = 1.020, P < 0.001) and the Ts-Dif (OR = 1.011, P = 0.034) were independent determinants of significant functional MR (defined by EROA ≥20 mm2). From the receiver-operating characteristic curve, the tenting area of 2.7 cm2 (sensitivity 83%, specificity 82%, AUC 0.86, P < 0.001) and the Ts-Dif of 85 ms (sensitivity 66%, specificity 72%, AUC 0.74, P < 0.001) were associated with significant functional MR. The assessment of Ts-Dif showed an incremental value over the mitral valve tenting area for determining functional MR (χ2 = 53.92 vs.49.11, P = 0.028). Conclusion This cross-sectional study showed that LV global, but not regional systolic dyssynchrony, is a determinant of significant functional MR in patients with LV systolic dysfunction, and is incremental to the tenting area that is otherwise the strongest factor for mitral valve deformation. |
| 收录类别 | SCI |
| 原文出处 | http://eurheartj.oxfordjournals.org/content/34/10/767 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5251]  |
| 专题 | 深圳先进技术研究院_其他 |
| 作者单位 | EUROPEAN HEART JOURNAL |
| 推荐引用方式 GB/T 7714 | Liang Yu-Jia,Zhang Qing,Fang Fang,et al. Incremental value of global systolic dyssynchrony in determining the occurrence of functional mitral regurgitation in patients with left ventricular systolic dysfunction[J]. EUROPEAN HEART JOURNAL,2013. |
| APA | Liang Yu-Jia.,Zhang Qing.,Fang Fang.,Lee Alex Pui-Wai.,Liu Ming.,...&Yu Cheuk-Man.(2013).Incremental value of global systolic dyssynchrony in determining the occurrence of functional mitral regurgitation in patients with left ventricular systolic dysfunction.EUROPEAN HEART JOURNAL. |
| MLA | Liang Yu-Jia,et al."Incremental value of global systolic dyssynchrony in determining the occurrence of functional mitral regurgitation in patients with left ventricular systolic dysfunction".EUROPEAN HEART JOURNAL (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。