Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways
文献类型：期刊论文
| 作者 | Jia Xiao; Chi Tat Ho; Emily C. Liong; Amin A. Nanji; Tung Ming Leung; Thomas Yue Huen Lau; Man Lung Fung; George L. Tipoe |
| 刊名 | EUROPEAN JOURNAL OF NUTRITION
 |
| 出版日期 | 2014 |
| 英文摘要 | To investigate the protective mechanisms of an 85 % pure extract of (-) epigallocatechin gallate (EGCG) in the development of fibrosis, oxidative stress andinflammation in a recently developed dietary-induced animal model of non-alcoholic fatty liver disease (NAFLD). Female Sprague-Dawley rats were fed with either normal rat diet or high-fat diet for 8 weeks to develop NAFLD. For both treatments, rats were treated with or without EGCG (50 mg/kg, i.p. injection, 3 times per week). At the end, blood and liver tissue samples were obtained for histology, molecular, and biochemical analyses. Non-alcoholic fatty liver disease (NAFLD) rats showed significant amount of fatty infiltration, necrosis, fibrosis, and inflammation. This was accompanied by a significant expressional increase in markers for fibrosis, oxidative stress, and inflammation. TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways were also activated. Treatment with EGCG improved hepatic histology (decreased number of fatty score, necrosis, and inflammatory foci), reduced liver injury (from similar to 0.5 to similar to 0.3 of ALT/AST ratio), attenuated hepatic changes including fibrosis (reduction in Sirius Red and synaptophysin-positive stain) with down-regulation in the expressions of key pathological oxidative (e.g. nitrotyrosine formation) and pro-inflammatory markers (e.g. iNOS, COX-2, and TNF-alpha). EGCG treatment also counteracted the activity of TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways. Treatment with EGCG did not affect the healthy rats. Epigallocatechin gallate (EGCG) reduced the severity of liver injury in an experimental model of NAFLD associated with lower concentration of pro-fibrogenic,oxidative stress, and pro-inflammatory mediators partly through modulating the activities of TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways. Therefore, green tea polyphenols and EGCG are useful supplements in the prevention of NAFLD. |
| 收录类别 | SCI |
| 原文出处 | http://link.springer.com/article/10.1007/s00394-013-0516-8 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6196]  |
| 专题 | 深圳先进技术研究院_其他 |
| 作者单位 | EUROPEAN JOURNAL OF NUTRITION |
| 推荐引用方式 GB/T 7714 | Jia Xiao,Chi Tat Ho,Emily C. Liong,et al. Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways[J]. EUROPEAN JOURNAL OF NUTRITION,2014. |
| APA | Jia Xiao.,Chi Tat Ho.,Emily C. Liong.,Amin A. Nanji.,Tung Ming Leung.,...&George L. Tipoe.(2014).Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways.EUROPEAN JOURNAL OF NUTRITION. |
| MLA | Jia Xiao,et al."Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways".EUROPEAN JOURNAL OF NUTRITION (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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