ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells
文献类型：期刊论文
| 作者 | Xiao Yiren; Jiang Zhiwu; Li Yin; Ye Wei; Jia Bei; Zhang Minjie; Xu Yan; Wu Donghai; Lai Liangxue; Chen Yaoyu |
| 刊名 | HAEMATOLOGICA
 |
| 出版日期 | 2015 |
| 英文摘要 | Successful expansion of hematopoietic stem cells would benefit the use of hematopoietic stem cell transplants in the clinic. Several angiopoietin-like proteins, including angiopoietin-like 7, can support the activity of hematopoietic stem cells. However, effects of ANGPTL7 on human hematopoietic stem cells and the downstream signaling cascade activated by ANGPTL7 are poorly understood. Here, we established a human hematopoietic stem and progenitor cell-supportive mouse fetal liver cell line that specifically expressed the Angptl7 protein. Furthermore, we found ANGPTL7 is capable of stimulating human hematopoietic stem and progenitor cell expansion and increasing the repopulation activities of human hematopoietic progenitors in xenografts. RNA-sequencing analysis showed that ANGPTL7 activated the expression of CXCR4, HOXB4 and Wnt downstream targets in human hematopoietic progenitors. In addition, chemical manipulation of Wnt signaling diminished the effects of ANGPTL7 on human hematopoietic stem and progenitor cells in culture. In summary, we identify the secreted growth factor ANGPTL7 as a regulator of both human hematopoietic stem and progenitor cell expansion and regeneration. |
| 收录类别 | SCI |
| 原文出处 | http://www.haematologica.org/content/100/5/585.full-text.pdf+html |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/9158]  |
| 专题 | 深圳先进技术研究院_其他 |
| 作者单位 | HAEMATOLOGICA |
| 推荐引用方式 GB/T 7714 | Xiao Yiren,Jiang Zhiwu,Li Yin,et al. ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells[J]. HAEMATOLOGICA,2015. |
| APA | Xiao Yiren.,Jiang Zhiwu.,Li Yin.,Ye Wei.,Jia Bei.,...&DuanqingLi Peng.(2015).ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells.HAEMATOLOGICA. |
| MLA | Xiao Yiren,et al."ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells".HAEMATOLOGICA (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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