Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells
文献类型：期刊论文
| 作者 | Xiao Yiren; Wei Xinru; Jiang Zhiwu; Wang Xiangmeng; Ye Wei; Liu Xin; Zhang Minjie; Xu Yan; Wu Donghai; Lai Liangxue |
| 刊名 | JOURNAL OF HEMATOLOGY & ONCOLOGY
 |
| 出版日期 | 2015 |
| 英文摘要 | Successful expansion of hematopoietic stem cells (HSCs) would benefit the use of HSC transplants in the clinic. Angiopoietin-like 7 promotes the expansion of hematopoietic stem and progenitor cells (HSPC) in vitro and ex vivo. However, the impact of loss of Angptl7 on HSPCs in vivo has not been characterized. Here, we generated Angptl7-deficient mice by TALEN-mediated gene targeting and found that HSC compartments in Angptl7-null mice were compromised. In addition, wild type (WT) HSPCs failed to repopulate in the BM of Angptl7-null mice after serial transplantations while the engraftment of Angptl7-deficient HSPCs in WT mice was not impaired. These results suggest that Angptl7 is required for HSPCs repopulation in a non-cell autonomous manner. |
| 收录类别 | SCI |
| 原文出处 | http://www.jhoonline.org/content/8/1/7 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/9162]  |
| 专题 | 深圳先进技术研究院_其他 |
| 作者单位 | JOURNAL OF HEMATOLOGY & ONCOLOGY |
| 推荐引用方式 GB/T 7714 | Xiao Yiren,Wei Xinru,Jiang Zhiwu,et al. Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells[J]. JOURNAL OF HEMATOLOGY & ONCOLOGY,2015. |
| APA | Xiao Yiren.,Wei Xinru.,Jiang Zhiwu.,Wang Xiangmeng.,Ye Wei.,...&Li Peng.(2015).Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells.JOURNAL OF HEMATOLOGY & ONCOLOGY. |
| MLA | Xiao Yiren,et al."Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells".JOURNAL OF HEMATOLOGY & ONCOLOGY (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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