Defining Biological Networks for Noise Buffering and Signaling Sensitivity Using Approximate Bayesian Computation
文献类型：期刊论文
| 作者 | Wang, Shuqiang; Shen, Yanyan; Shi, Changhong; Wang, Tao; Wei, Zhiming; Li, Hanxiong |
| 刊名 | SCIENTIFIC WORLD JOURNAL
 |
| 出版日期 | 2014 |
| 英文摘要 | Reliable information processing in cells requires high sensitivity to changes in the input signal but low sensitivity to random fluctuations in the transmitted signal. There are often many alternative biological circuits qualifying for this biological function. Distinguishing theses biological models and finding the most suitable one are essential, as such model ranking, by experimental evidence, will help to judge the support of the working hypotheses forming each model. Here, we employ the approximate Bayesian computation (ABC) method based on sequential Monte Carlo (SMC) to search for biological circuits that can maintain signaling sensitivity while minimizing noise propagation, focusing on cases where the noise is characterized by rapid fluctuations. By systematically analyzing three-component circuits, we rank these biological circuits and identify three-basic-biological-motif buffering noise while maintaining sensitivity to long-term changes in input signals. We discuss in detail a particular implementation in control of nutrient homeostasis in yeast. The principal component analysis of the posterior provides insight into the nature of the reaction between nodes. |
| 收录类别 | SCI |
| 原文出处 | http://www.hindawi.com/journals/tswj/2014/625754/ |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6016]  |
| 专题 | 深圳先进技术研究院_数字所 |
| 作者单位 | SCIENTIFIC WORLD JOURNAL |
| 推荐引用方式 GB/T 7714 | Wang, Shuqiang,Shen, Yanyan,Shi, Changhong,et al. Defining Biological Networks for Noise Buffering and Signaling Sensitivity Using Approximate Bayesian Computation[J]. SCIENTIFIC WORLD JOURNAL,2014. |
| APA | Wang, Shuqiang,Shen, Yanyan,Shi, Changhong,Wang, Tao,Wei, Zhiming,&Li, Hanxiong.(2014).Defining Biological Networks for Noise Buffering and Signaling Sensitivity Using Approximate Bayesian Computation.SCIENTIFIC WORLD JOURNAL. |
| MLA | Wang, Shuqiang,et al."Defining Biological Networks for Noise Buffering and Signaling Sensitivity Using Approximate Bayesian Computation".SCIENTIFIC WORLD JOURNAL (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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