Integrated miRNA profiling and bioinformatics analyses reveal potential causative miRNAs in gastric adenocarcinoma
文献类型：期刊论文
| 作者 | Xiaojing Zhang; Yin Peng; Zhe Jin; Weiling Huang; Yulan Cheng; Yudan Liu; Xianling Feng; Mengting Yang; Yong Huang; Zhenfu Zhao |
| 刊名 | Oncotarget
 |
| 出版日期 | 2015 |
| 英文摘要 | Gastric cancer (GC) is one of the leading causes of cancer-related death in China and worldwide. The discovery of microRNAs (miRNAs/miRs) has provided a new guideline for developing diagnostic biomarkers and effective therapeutic targets in GC. MiRNA microarray analyses of benign and malignant gastric epithelial cell lines (HFE145, NCI-N87, MKN28, RF1, KATO III and RF48) were performed. 16 significantly dysregulated miRNAs were found. 11 of them were validated by real-time qRT-PCR. Based on miRWalk online database scans, 2,532 potential mRNA targets of these 16 miRNAs were identified. Bioinformatic analyses suggested that these dysregulated miRNAs and predicted targets were principally involved in tumor pathogenesis, MAPK signaling, and apoptosis. Finally, miRNA-gene network analyses identified miR-125b as a crucial miRNA in the development of GC. Taken together, these findings imply that dysregulated expression of miRNAs and their potential target mRNAs are prominently involved in the pathogenesis of GC. These results suggest that dysregulated miRNAs may serve as potential biomarkers and therapeutic targets for GC. |
| 收录类别 | SCI |
| 原文出处 | http://europepmc.org/abstract/med/26460735 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6853]  |
| 专题 | 深圳先进技术研究院_数字所 |
| 作者单位 | Oncotarget |
| 推荐引用方式 GB/T 7714 | Xiaojing Zhang,Yin Peng,Zhe Jin,et al. Integrated miRNA profiling and bioinformatics analyses reveal potential causative miRNAs in gastric adenocarcinoma[J]. Oncotarget,2015. |
| APA | Xiaojing Zhang.,Yin Peng.,Zhe Jin.,Weiling Huang.,Yulan Cheng.,...&Stephen J. Meltzer.(2015).Integrated miRNA profiling and bioinformatics analyses reveal potential causative miRNAs in gastric adenocarcinoma.Oncotarget. |
| MLA | Xiaojing Zhang,et al."Integrated miRNA profiling and bioinformatics analyses reveal potential causative miRNAs in gastric adenocarcinoma".Oncotarget (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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