Post-transcriptional regulation tends to attenuate the mRNA noise and to increase the mRNA gain
文献类型：期刊论文
| 作者 | Shi Changhong; Wang Shuqiang; Zhou Tianshou; Jiang Yiguo |
| 刊名 | PHYSICAL BIOLOGY
 |
| 出版日期 | 2015 |
| 英文摘要 | Post-transcriptional regulation is ubiquitous in prokaryotic and eukaryotic cells, but how it impacts gene expression remains to be fully explored. Here, we analyze a simple gene model in which we assume that mRNAs are produced in a constitutive manner but are regulated post-transcriptionally by a decapping enzyme that switches between the active state and the inactive state. We derive the analytical mRNA distribution governed by a chemical master equation, which can be well used to analyze the mechanism of how post-transcription regulation influences the mRNA expression level including the mRNA noise. We demonstrate that the mean mRNA level in the stochastic case is always higher than that in the deterministic case due to the stochastic effect of the enzyme, but the size of the increased part depends mainly on the switching rates between two enzyme states. More interesting is that we find that in contrast to transcriptional regulation, post-transcriptional regulation tends to attenuate noise in mRNA. Our results provide insight into the role of post-transcriptional regulation in controlling the transcriptional noise. |
| 收录类别 | SCI |
| 原文出处 | http://iopscience.iop.org/article/10.1088/1478-3975/12/5/056002/meta;jsessionid=7A44A7CF46110CB7D4664D05F121CD72.c5.iopscience.cld.iop.org# |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6863]  |
| 专题 | 深圳先进技术研究院_数字所 |
| 作者单位 | PHYSICAL BIOLOGY |
| 推荐引用方式 GB/T 7714 | Shi Changhong,Wang Shuqiang,Zhou Tianshou,et al. Post-transcriptional regulation tends to attenuate the mRNA noise and to increase the mRNA gain[J]. PHYSICAL BIOLOGY,2015. |
| APA | Shi Changhong,Wang Shuqiang,Zhou Tianshou,&Jiang Yiguo.(2015).Post-transcriptional regulation tends to attenuate the mRNA noise and to increase the mRNA gain.PHYSICAL BIOLOGY. |
| MLA | Shi Changhong,et al."Post-transcriptional regulation tends to attenuate the mRNA noise and to increase the mRNA gain".PHYSICAL BIOLOGY (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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