Quantitative Dynamics-Activity Relationship: Dynamics of Intrinsically Disordered Regions in the Notch 1 Transcription Complex Mediate Gene Transcription
文献类型：会议论文
| 作者 | Fung-Ming Siu |
| 出版日期 | 2015 |
| 会议名称 | MMHS-2015 |
| 会议地点 | Shanghai, China |
| 英文摘要 | Transcription complexes are comprised of a DNA-bound transcription factor and coactivator proteins that are held together by cooperative and allosteric interactions. Understanding the mechanisms of action of transcription complexes continues to be a great challenge in chemical biology. The DNA-CSL-ICN-MAML1 Notch1 transcription complex (NTC) composes of a DNA-bound transcription factor (CSL: CBF1, Suppressor of Hairless, Lag-1), an intracellular domain of Notch1 receptor (ICN) and a mastermind-like family coactivator protein (MAML1). Mutation or aberrant regulation of the transcription complexes are associated with human diseases including congenital disorders, cardiovascular diseases, and cancers. As a proof-of-concept study, we performed a quantitative dynamics-activity relationship (QDAR) to analyze the dynamic properties of the IDRs in the NTC in relation to the transcriptional activity. Our study revealed a log-linear and anti-correlated relationship between the dynamic 批roperties of intrinsically disordered regions (IDRs) in the Notch1 transcription complex (NTC) and the transcriptional activity. We concluded that rigidified IRDs mediate binding of cofactors and dimerization, and leading to transcriptional activation. |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6987]  |
| 专题 | 深圳先进技术研究院_数字所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Fung-Ming Siu. Quantitative Dynamics-Activity Relationship: Dynamics of Intrinsically Disordered Regions in the Notch 1 Transcription Complex Mediate Gene Transcription[C]. 见:MMHS-2015. Shanghai, China. |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。