A novel low-toxic liposomal adjuvant: Different liposome compositions regulate monocyte activation and viability
文献类型：会议论文
| 作者 | Ma Yifan; Zhou Dongmei; Xie Xiaofang; Dong Bohan; Zhuang Yan; Zheng Mingbin |
| 出版日期 | 2009 |
| 会议名称 | 2nd International Symposium on Applied Sciences in Biomedical and Communication Technologies |
| 英文摘要 | Liposomes are nanoparticles consisting of phospholipid-bilayer membranes and aqueous compartments. They can effectively incorporate both hydrophobic and hydrophilic molecules, and therefore have been widely applied as a carrier for gene and drug delivery. Moreover, liposomes are considered as a novel vaccine delivery system, which encapsulate both Antigen (Ag) and immunomodulatory agents, facilitating Ag delivery to specific immune cells in vivo. Till date, liposomal vaccines against various diseases, such as cancer, HIV, Hepatitis B and malaria, have been investigated and found to be safe. However, their immunogenicity remains to be further improved. Although conventional liposomes are usually formulated with neutral and/or negatively charged lipids, many studies indicated that the cationic liposomes with positive surface charge more effectively enhanced Ag-specific immune response and promoted vaccine-induced anti-cancer responses than other liposomes. On the other hand, cationic liposomes at a high concentration significantly induced apoptosis of dendritic cells and suppressed immune response, suggesting the immunotoxic effect. In the present study, we incorporated 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), a neutral lipid into dioleoyl-3-trimethylammoniumpropane (DOTAP), a cationic liposome, and investigate the effect of different liposome formulations on monocyte activation and viability. Our aim is to develop a safe and effective liposomal adjuvant for vaccine delivery. |
| 收录类别 | EI |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/2567]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | 2009 |
| 推荐引用方式 GB/T 7714 | Ma Yifan,Zhou Dongmei,Xie Xiaofang,et al. A novel low-toxic liposomal adjuvant: Different liposome compositions regulate monocyte activation and viability[C]. 见:2nd International Symposium on Applied Sciences in Biomedical and Communication Technologies. |
入库方式： OAI收割
来源：深圳先进技术研究院
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