Therapeutic ultrasound microbubbles carrying paclitaxel and LyP-1 peptide: Preparation, characterization and application to ultrasonic assisted chemotherapy in breast cancer cells
文献类型：会议论文
| 作者 | Yan, Fei; Li, Xiang; Jin, Qiaofeng; Zhang, Zidong; Lu, Minhua; Zheng, Hairong |
| 出版日期 | 2010 |
| 会议名称 | 2010 IEEE International Ultrasonics Symposium, IUS 2010 |
| 会议地点 | San Diego, CA, United states |
| 英文摘要 | We have developed a novel lipid ultrasonic microbubble (MB) carrying paclitaxel (PTX) and LyP-1 peptides and investigated its tumor-targeted efficiency and chemotherapy effect in vitro. Results showed the attachment of targeted drug-loaded MBs to human MDA-MB-231 breast cancer cells was highly efficient and stable under both static and dynamic conditions. Also, the targeted drug-loaded MBs showed an excellent acoustic destructibility, with lowest half life (t1/2) of about 43 s. In addition, the cell viability treated with targeted PTX-loaded MBs was 24.01% lower than that of non-targeted PTX-loaded MBs (p<0.01) and 54.74% lower than that of non-targeted unloaded MBs (p<0.01) when ultrasound was utilized. The study indicated the LyP-1 coated PTX-loaded MBs significantly increased the anti-tumor efficacy, which may be used as a potential chemotherapy for ultrasound assisted breast cancer treatment. |
| 收录类别 | EI |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/3006]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | 2010 |
| 推荐引用方式 GB/T 7714 | Yan, Fei,Li, Xiang,Jin, Qiaofeng,et al. Therapeutic ultrasound microbubbles carrying paclitaxel and LyP-1 peptide: Preparation, characterization and application to ultrasonic assisted chemotherapy in breast cancer cells[C]. 见:2010 IEEE International Ultrasonics Symposium, IUS 2010. San Diego, CA, United states. |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。