Enhanced ambient pressure sensitivity of the subharmonic signal from ultrasound contrast microbubbles
文献类型：会议论文
| 作者 | Fei Li; Feiyan Cai; Long Meng; Qiaofeng Jin; Hairong Zheng; Deyu Li |
| 出版日期 | 2013 |
| 会议名称 | 2013 IEEE International Ultrasonics Symposium, IUS 2013 |
| 会议地点 | Prague, Czech republic |
| 英文摘要 | Microbubble ultrasound contrast agent (UCA) has been well recognized as a potential noninvasive tool for the blood pressure measurement. A decrease in subharmonic amplitude of 9 to 12 dB has been reported for Levovist, Optison, Definity, Sonazoid, and SonoVue for ambient overpressure values around 180 mmHg. However, a pressure resolution of 3 mmHg is desirable in medical diagnostics, it is still necessary to enhance the pressure sensitivity for the method based on the subharmonic amplitude as a function of local pressure. The purpose of this study was to improve the ambient pressure sensitivity of the subharmonic amplitude by optimizing acoustic parameters in in vitro experiments. The acoustic scattering measurement was carried out at different acoustic parameters, and it was demonstrated for SonoVue by us that the subharmonic amplitude reduced by 10.9 dB at the driving frequency of 4 MHz and the acoustic pressure of 450 kPa (mechanical index MI = 0.225), 19.8 dB at 4 MHz and 500 kPa (MI = 0.25), and 17.6 dB at 1.33 MHz and 350 kPa (MI = 0.3), respectively, when the overpressure increased to 180 mmHg. The results showed the effect of the mechanical index on the ambient pressure sensitivity of subharmonic amplitude, and indicated the existence of a MI threshold ( ≈ 0.23) at which the sensitivity can be enhanced significantly. |
| 收录类别 | EI |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4938]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | 2013 |
| 推荐引用方式 GB/T 7714 | Fei Li,Feiyan Cai,Long Meng,et al. Enhanced ambient pressure sensitivity of the subharmonic signal from ultrasound contrast microbubbles[C]. 见:2013 IEEE International Ultrasonics Symposium, IUS 2013. Prague, Czech republic. |
入库方式： OAI收割
来源：深圳先进技术研究院
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