A novel compact linear -array based photoacoustic handheld probe towards clinical translation for sentinel lymph node mapping
文献类型：会议论文
| 作者 | Mucong Li; Chengbo Liu; Liang Song |
| 出版日期 | 2015 |
| 会议名称 | The International Conference on Biomedical and Health Informatics 2015（ICBHI） |
| 会议地点 | 海口 |
| 英文摘要 | Abstract—Breast cancer is the leading threat to women health both in the developed and developing countries around the world. Sentinel lymph node (SLN) biopsy has become the standard of care for the staging of this disease over the past few decades. Conventional ultrasound lacks the capability to identify the SLNs. Thus, during the procedure, radioactive tracers and dyes are injected and an open surgery is required to identify the dye accumulated SLNs. As a rapidly growing technology, photoacoustic (PA) imaging is gaining widespread attention due to its excellent imaging contrast as well as high resolution for deep imaging. Therefore, handheld ultrasound linear array based PA systems have been developed by several groups for SLN identification over the past few years, which were demonstrated to be able to identify SLNs noninvasively, and can potentially eliminate the need for radioactive tracers and open surgeries. In most of these systems, the light excitation and ultrasound detection are not designed coaxially, and thus high laser pulse energy is usually needed to produce PA images with a decent signal-to-noise ratio. For one recently reported coaxial based design, the imaging probe is very bulky and complex, making it unfriendly for clinical use and translation. In this study, we developed a handheld ultrasound linear array based real-time photoacousitc tomography system. Compared with previously reported systems, our system is more compact and clinically friendly, and the excitation laser energy is more efficiently utilized. A novel optical-acoustic co-axial probe design (Figure 1) was proposed in our system to offer the system a high signal-to-noise ratio as well as deep imaging capability, under relatively low laser energy excitation. GPU computation was also applied in the system to accelerate the imaging reconstruction speed, guaranteeing a real-time frame rate display. The system was validated in both in vitro and in vivo studies, by imaging silver needles in intra-lipid containing agar phantom as well as a rat sentinel lymph node (Figure 2) under the skin surface in vivo, respectively. The significantly improved imaging SNR with low laser pulse energy, high imaging depth, together with the reduced probe |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7215]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Mucong Li,Chengbo Liu,Liang Song. A novel compact linear -array based photoacoustic handheld probe towards clinical translation for sentinel lymph node mapping[C]. 见:The International Conference on Biomedical and Health Informatics 2015（ICBHI）. 海口. |
入库方式： OAI收割
来源：深圳先进技术研究院
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