The Study of Open Fracture Healing in Collagen-Induced Arthritis Rat Model
文献类型：会议论文
| 作者 | Yiping Hu; Yingya Ma; Jie Wang; Ye Yue; Wenxiang Cheng; and Peng Zhang |
| 出版日期 | 2015 |
| 会议名称 | 2015 SICOT |
| 会议地点 | 广州 |
| 英文摘要 | Objective: Patients with rheumatoid arthritis (RA) are at increased risk for developing osteoporosis and fractures compared to controls. This risk is further increased since a majority of patients with RA also receive concomitant heal difficult when fracture. In addition, multiple factors lead to systemic osteoporosis. These conditions cause decreased bone mineral density and bone quality, and expose patients to an increased risk of fracture. Methods: To observe the fracture heal in RA model, after 15days the onset of arthritis a mid-shaft femur fracture model (RA+F group) was established (normal rats fracture model as control group NF group). Femurs were then harvested at 8 weeks, 16 weeks after fracture for micro-computed tomography (MicroCT), X-Ray, histology test. Results: The Micro CT images demonsrated the remodeling of the calcified callus, at 8 and 16 weeks after fracture, fracture gap could be clearly observed in RA+F group , while NF group better heal than RA+F group. NF group and the periosteal callus appeared to be homogenously filled with newly formed bone. X-Ray observed the results same as Micro CT images. Fracture gap clearly observed in RA+F group. Sections obtained from the NF group after fracture showed more mature lamellar bone in the fracture gap, with more integrity, thick and continuous callus compared to RA+F group. Conclusion: Multiple factors lead to systemic osteoporosis remarkably induced decrease in mineralized tissue and not well connected microstructure in newly formed callus, which may explain why RA patients has high risk of fracture and difficult heal when fracture. |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7308]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Yiping Hu,Yingya Ma,Jie Wang,et al. The Study of Open Fracture Healing in Collagen-Induced Arthritis Rat Model[C]. 见:2015 SICOT. 广州. |
入库方式： OAI收割
来源：深圳先进技术研究院
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