MR study of postnatal development of myocardial structure and left ventricular function
文献类型：期刊论文
| 作者 | Wu Yin; Wu Ed X. |
| 刊名 | JOURNAL OF MAGNETIC RESONANCE IMAGING
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:1页码:47-53 |
| 英文摘要 | PURPOSE: To investigate postnatal development of left ventricular (LV) cardiac function and myocardium structure. MATERIALS AND METHODS: In vivo cardiac MR and ex vivo diffusion tensor imaging (DTI) were performed in normal Sprague-Dawley rats at postnatal day 2, 4, 7, 14, 21, 28, and 56 (N = 6 per group). RESULTS: Morphologically, LV size increased with age. Functionally, stroke volume and cardiac output increased. Heart rate increased gradually and became stable after day 14. On average, ejection fraction increased within the first 4 days, decreased at day 7, gradually increased until day 21, and became stable afterward. Structurally, double-helical myocardial structure was found as early as day 2. Myocardial fiber parameters, described by fractional anisotropy, mean apparent diffusion coefficient, and axial diffusivity, increased within the first 4 days. Then radial diffusivity increased until day 7 while other parameters decreased up to day 56. CONCLUSION: Postnatal heart development was documented by MRI. DTI findings are in agreement with the two known stages of early postnatal growth: hyperplasia and hypertrophy. These results can serve as the baselines for study of postnatal heart developmental abnormalities. They also demonstrate the ability of DTI to reveal microstructural alterations in myocardium. |
| 收录类别 | SCI |
| 原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/jmri.21814/pdf |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/2532]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | JOURNAL OF MAGNETIC RESONANCE IMAGING |
| 推荐引用方式 GB/T 7714 | Wu Yin,Wu Ed X.. MR study of postnatal development of myocardial structure and left ventricular function[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2009,30(1):47-53. |
| APA | Wu Yin,&Wu Ed X..(2009).MR study of postnatal development of myocardial structure and left ventricular function.JOURNAL OF MAGNETIC RESONANCE IMAGING,30(1),47-53. |
| MLA | Wu Yin,et al."MR study of postnatal development of myocardial structure and left ventricular function".JOURNAL OF MAGNETIC RESONANCE IMAGING 30.1(2009):47-53. |
入库方式： OAI收割
来源：深圳先进技术研究院
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