Therapeutic ultrasonic microbubbles carrying paclitaxel and LyP-1 peptide preparation, characterization and application to ultrasound-assisted chemotherapy in breast cancer cells
文献类型：期刊论文
| 作者 | Fei Yan; Xiang Li; Qiaofeng Jin; Chunxiang Jiang; Zidong Zhang; Tao Ling; Bensheng Qiu; Hairong Zheng |
| 刊名 | ULTRASOUND IN MEDICINE AND BIOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 37期号:5页码:768-79 |
| 英文摘要 | The aim of this work was to develop a novel targeted drug-loaded microbubble (MB) and to investigate its chemotherapy effect in vitro. Paclitaxel (PTX)-loaded lipid MBs were prepared by a mechanical vibration technique. The LyP-1, a breast tumor homing peptide, was coated onto the surface of PTX-loaded MBs through biotin-avidin linkage. The resulting targeted drug-loaded MBs were characterized and applied to ultrasound-assisted chemotherapy in breast cancer cells. Our results showed the ultrasonic MBs were able to achieve 43%-63% of drug encapsulation efficiency, depending on drug loading amount. The binding affinity assay indicated the attachment of targeted MBs to human MDA-MB-231 breast cancer cells was highly efficient and stable even with ultrasonic irradiation on. The cellular uptake efficiency of payload in targeted MBs was 3.71-, 4.95-, 7.43- and 7.66-fold higher than that of non-targeted MBs at the applied ultrasound time of 30, 60, 90 and 120 s, respectively. In addition, the cell proliferation inhibition assay showed the cell viability of targeted PTX-loaded MBs was significantly lower than that of non-targeted PTX-loaded MBs and non-targeted unloaded MBs when ultrasound was utilized. In conclusion, the study indicated the LyP-1-coated PTX-loaded MBs significantly increased the antitumor efficacy and can be used as a potential chemotherapy approach for ultrasound-assisted breast cancer treatment. (E-mail: hr.zheng@siat.ac.cn) (C) 2011 World Federation for Ultrasound in Medicine & Biology. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0301562911001013 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/3450]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | ULTRASOUND IN MEDICINE AND BIOLOGY |
| 推荐引用方式 GB/T 7714 | Fei Yan,Xiang Li,Qiaofeng Jin,et al. Therapeutic ultrasonic microbubbles carrying paclitaxel and LyP-1 peptide preparation, characterization and application to ultrasound-assisted chemotherapy in breast cancer cells[J]. ULTRASOUND IN MEDICINE AND BIOLOGY,2011,37(5):768-79. |
| APA | Fei Yan.,Xiang Li.,Qiaofeng Jin.,Chunxiang Jiang.,Zidong Zhang.,...&Hairong Zheng.(2011).Therapeutic ultrasonic microbubbles carrying paclitaxel and LyP-1 peptide preparation, characterization and application to ultrasound-assisted chemotherapy in breast cancer cells.ULTRASOUND IN MEDICINE AND BIOLOGY,37(5),768-79. |
| MLA | Fei Yan,et al."Therapeutic ultrasonic microbubbles carrying paclitaxel and LyP-1 peptide preparation, characterization and application to ultrasound-assisted chemotherapy in breast cancer cells".ULTRASOUND IN MEDICINE AND BIOLOGY 37.5(2011):768-79. |
入库方式： OAI收割
来源：深圳先进技术研究院
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