Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer
文献类型：期刊论文
| 作者 | Wei Zheng, Dong Li, Shuxia Li, Yan Zeng, Yanqi Yang, and Jianan Y. Qu |
| 刊名 | OPTICS LETTERS
 |
| 出版日期 | 2011 |
| 卷号 | 36期号:18页码:3620-2622 |
| 英文摘要 | During precancer development in epithelium, neoplastic cells remodel the underlying stroma, for example, the basement membrane, capillaries, fibroblasts, and extracellular matrix. The purpose of this study is to investigate the relationship between the nonlinear optical signals from the collagen matrix in stroma and the progression of early epithelial carcinogenesis. Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) signals were measured from the stroma of hamster oral cheek pouch in vivo. We found that three features, including the intensity ratio of TPEF over SHG, the spatial frequency distribution, and the texture feature of SHG images, provide the quantitative identification of epithelial precancer at different pathologic stages. We demonstrated that the combination of all three features by using a support vector machine algorithm can significantly improve the accuracy in the detection of epithelial precancer. |
| 收录类别 | SCI |
| 原文出处 | https://www.osapublishing.org/ol/fulltext.cfm?uri=ol-36-18-3620&id=222448 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/3459]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | OPTICS LETTERS |
| 推荐引用方式 GB/T 7714 | Wei Zheng, Dong Li, Shuxia Li, Yan Zeng, Yanqi Yang, and Jianan Y. Qu. Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer[J]. OPTICS LETTERS,2011,36(18):3620-2622. |
| APA | Wei Zheng, Dong Li, Shuxia Li, Yan Zeng, Yanqi Yang, and Jianan Y. Qu.(2011).Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer.OPTICS LETTERS,36(18),3620-2622. |
| MLA | Wei Zheng, Dong Li, Shuxia Li, Yan Zeng, Yanqi Yang, and Jianan Y. Qu."Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer".OPTICS LETTERS 36.18(2011):3620-2622. |
入库方式： OAI收割
来源：深圳先进技术研究院
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