Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling
文献类型：期刊论文
| 作者 | Fan Yang; Dazhi Yang; Jie Tu; Qixin Zheng; Lintao Cai; Liping Wang |
| 刊名 | STEM CELLS
 |
| 出版日期 | 2011 |
| 卷号 | 29期号:6页码:981-991 |
| 英文摘要 | trontium ranelate is a newly approved drug that can reduce the risk of vertebral fracture, which is attributed to its dual function in increasing the bone formation and decreasing the bone resorption. Strontium-containing hydroxyapatite was also demonstrated to stimulate the osteoblast activity and inhibit the osteoclast activity. However, the molecular mechanisms of strontium underlying such beneficial effects were still not fully understood. In this study, we investigated the effects of strontium on the osteogenic differentiation of human mesenchymal stem cells (MSCs) and its related mechanism; its osteogenic potential was also evaluated using a calvarial defect model in rats. We found that strontium could enhance the osteogenic differentiation of the MSCs, with upregulated extracellular matrix (ECM) gene expression and activated Wnt/β-catenin pathway. After transplanting the collagen-strontium-substituted hydroxyapatite scaffold into the bone defect region, histology and computed tomography scanning revealed that in vivo bone formation was significantly enhanced; the quantity of mature and remodeled bone substantially increased and ECM accumulated. Interestingly, strontium induced an increase of β-catenin expression in newly formed bone area. In this study, we showed for the first time that strontium could stimulate the β-catenin expression in vitro and in vivo, which might contribute to the enhanced osteogenic differentiation of MSCs and in vivo bone formation. |
| 收录类别 | SCI |
| 原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/stem.646/full |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/3468]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | STEM CELLS |
| 推荐引用方式 GB/T 7714 | Fan Yang,Dazhi Yang,Jie Tu,et al. Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling[J]. STEM CELLS,2011,29(6):981-991. |
| APA | Fan Yang,Dazhi Yang,Jie Tu,Qixin Zheng,Lintao Cai,&Liping Wang.(2011).Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling.STEM CELLS,29(6),981-991. |
| MLA | Fan Yang,et al."Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling".STEM CELLS 29.6(2011):981-991. |
入库方式： OAI收割
来源：深圳先进技术研究院
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