A comprehensive biological evaluation of ceramic nanoparticles as wear debris
文献类型：期刊论文
| 作者 | Y.F.Zhang,MPhil; Y.F.Zheng,PhD; L.Qin PhD |
| 刊名 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
 |
| 出版日期 | 2011 |
| 卷号 | 7期号:6页码:975-982 |
| 英文摘要 | Patients are exposed internally to nanoparticles (NPs) by wear mechanisms associated with total joint arthroplasty. This tissue-specific retention implies that the biological evaluation of NPs shall be integrative and niche targeting. Here, we report that ceramic zirconia and silicon nitride NPs interfere with MG63 cells' function and remarkably stimulate the secretion of TNF-α in RAW264.7 cells. However, alumina NPs significantly promote the alkaline phosphatase (ALP) activity of MG63 cells at low concentration and do not show irritation to macrophages. In this study, we prove that ceramic materials at nanoscale are bioactive to cells. These findings also suggest that a more rational paradigm for the biosafety evaluation of NPs than is currently in place is needed before their clinical applications. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S1549963411001663 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/3491]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE |
| 推荐引用方式 GB/T 7714 | Y.F.Zhang,MPhil,Y.F.Zheng,PhD,L.Qin PhD. A comprehensive biological evaluation of ceramic nanoparticles as wear debris[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2011,7(6):975-982. |
| APA | Y.F.Zhang,MPhil,Y.F.Zheng,PhD,&L.Qin PhD.(2011).A comprehensive biological evaluation of ceramic nanoparticles as wear debris.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,7(6),975-982. |
| MLA | Y.F.Zhang,MPhil,et al."A comprehensive biological evaluation of ceramic nanoparticles as wear debris".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 7.6(2011):975-982. |
入库方式： OAI收割
来源：深圳先进技术研究院
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