Experimental animal models of osteonecrosis
文献类型：期刊论文
| 作者 | Fan, Meng; Peng, Jiang; Qin, Ling; Lu, Shibi |
| 刊名 | Rheumatology international
 |
| 出版日期 | 2011 |
| 卷号 | 31期号:8页码:983-994 |
| 英文摘要 | Osteonecrosis (ON) or avascular necrosis (AVN) is a common bone metabolic disorder, mostly affecting femoral head. Although many biological, biophysical, and surgical methods have been tested to preserve the femoral head with ON, none has been proven fully satisfactory. It lacks consensus on an optimal approach for treatment. This is due, at least in part, to the lack of ability to systematically compare treatment efficacy using an ideal animal model that mimics full-range osteonecrosis of femoral head (ONFH) in humans with high incidence of joint collapse accompanied by reparative reaction adjacent to the necrotic bone in a reproducible and accessible way. A number of preclinical animal ON models have been established for testing potential efficacy of various modalities developed for prevention and treatment of ON before introduction into clinics for potential applications. This paper describes a number of different methods for creating animal experimental ON models. Advantages and disadvantages of such models are also discussed as reference for future research in battle against this important medical condition. |
| 收录类别 | SCI |
| 原文出处 | http://download.springer.com/static/pdf/127/art%253A10.1007%252Fs00296-011-1819-9.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00296-011-1819-9&token2=exp=1433421306~acl=%2Fstatic%2Fpdf%2F127%2Fart%25253A10.1007%25252Fs00296-011-1819-9.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs00296-011-1819-9*~hmac=34ee021768e168f6614f054eef050db57c013df9e629c28f43d27e06572ea5ca |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/3495]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Rheumatology international |
| 推荐引用方式 GB/T 7714 | Fan, Meng,Peng, Jiang,Qin, Ling,et al. Experimental animal models of osteonecrosis[J]. Rheumatology international,2011,31(8):983-994. |
| APA | Fan, Meng,Peng, Jiang,Qin, Ling,&Lu, Shibi.(2011).Experimental animal models of osteonecrosis.Rheumatology international,31(8),983-994. |
| MLA | Fan, Meng,et al."Experimental animal models of osteonecrosis".Rheumatology international 31.8(2011):983-994. |
入库方式： OAI收割
来源：深圳先进技术研究院
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