Cytotoxicity enhancement of DOX-liposome-containing microbubbles combined with ultrasound to the multi-drug resistant cell
文献类型：期刊论文
| 作者 | Zhiting Deng; Fei Yan; Lu Li,; Qiaofeng Jin; Fei Li; Hairong Zheng |
| 刊名 | The Journal of the Acoustical Society of America
 |
| 出版日期 | 2012 |
| 英文摘要 | Multidrug resistance (MDR) in cancer cells is a significant obstacle to successful cancer therapy. Doxorubicin (DOX) is very active chemotherapeutic agent for the treatment of breast cancer and the efficacy of DOX is also restricted by multidrug resistance.Ultrasound (US) targeted destruction of drug loaded microbubbles (MBs) is gaining more and more attention as a promising strategy for locally drug delivery. In this article, through avidinbiotin binding of DOX-containing liposomes to the microbubbles, we developed DOX-liposome-containing microbubbles in order to investigate its effect of enhancing cellular uptake and cytotoxicity of DOX against drug-resistant cancer cells. The results demonstrated that treatment of cells with ultrasound and DOX-liposome-containing microbubbles caused a significant higher drug uptake in DOX-resistant MCF-7 cells, compared with control (DOX-liposome). More importantly, a significant enhancement of tumor growth inhibition against DOX-resistant MCF-7 cells was found when using the drug-liposome-containing microbubbles combined with ultrasound.Compared with DOX-liposome treatment, the cytotoxicity effect was greatly enhanced from 21% to 60%. By further mechanism study, DOX-loaded microbubbles plus ultrasound induced significant apoptosis in MDR line of MCF-7 cells. Cytotoxicity enhancement of DOX-liposome-containing microbubbles combined with ultrasound to the multi-drug resistant cell. - ResearchGate. Available from: http://www.researchgate.net/publication/224035655_Cytotoxicity_enhancement_of_DOX-liposome-containing_microbubbles_combined_with_ultrasound_to_the_multi-drug_resistant_cell [accessed Jun 5, 2015]. |
| 收录类别 | 其他 |
| 原文出处 | http://scitation.aip.org/content/asa/journal/jasa/131/4/10.1121/1.4708690 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/3959]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | The Journal of the Acoustical Society of America |
| 推荐引用方式 GB/T 7714 | Zhiting Deng,Fei Yan,Lu Li,,et al. Cytotoxicity enhancement of DOX-liposome-containing microbubbles combined with ultrasound to the multi-drug resistant cell[J]. The Journal of the Acoustical Society of America,2012. |
| APA | Zhiting Deng,Fei Yan,Lu Li,,Qiaofeng Jin,Fei Li,&Hairong Zheng.(2012).Cytotoxicity enhancement of DOX-liposome-containing microbubbles combined with ultrasound to the multi-drug resistant cell.The Journal of the Acoustical Society of America. |
| MLA | Zhiting Deng,et al."Cytotoxicity enhancement of DOX-liposome-containing microbubbles combined with ultrasound to the multi-drug resistant cell".The Journal of the Acoustical Society of America (2012). |
入库方式： OAI收割
来源：深圳先进技术研究院
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