GABA Attenuates Amyloid Toxicity by Downregulating its Endocytosis and Improves Cognitive Impairment
文献类型：期刊论文
| 作者 | Xiaqin Sun; Xiaolu Meng; Jie Zhang; Yonghui Li; Liping Wang; Xiaoyan Qin; Nan Sui; Yan Zhang |
| 刊名 | JOURNAL OF ALZHEIMERS DISEASE
 |
| 出版日期 | 2012 |
| 英文摘要 | GABA (gamma-aminobutyric acid) receptor modulators have been investigated as a potential treatment strategy in Alzheimer's disease (AD). In the present study, we found that GABA levels were different in wild type (WT) and A beta PP/PS1 mouse brains. GABA downregulated amyloid-beta (A beta) uptake in neurons through the receptor for advanced glycation end-products. Therefore, relative high levels of GABA decreased cytotoxicity induced by A beta in WT mice. GABA treatment decreased basal levels of cell death and the cell death induced by hydrogen peroxide in WT and A beta PP/PS1 neurons. Application of GABA during early life before 2 months of age can improve cognitive function significantly in A beta PP/PS1 mice. However, GABA treatment at 6 and 8 months of age cannot improve water maze performance. Activating or suppressing GABA(A) receptors by optogenetic methods also confirmed that GABA activation before 2 months of age increased water maze performance in A beta PP/PS1 mice. Our data suggest that GABA administration during early life can be a potential treatment for AD. |
| 收录类别 | SCI |
| 原文出处 | http://wanglab.siat.ac.cn/wanglab_en/upload/publications/20140126105413.pdf |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/3968]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | JOURNAL OF ALZHEIMERS DISEASE |
| 推荐引用方式 GB/T 7714 | Xiaqin Sun,Xiaolu Meng,Jie Zhang,et al. GABA Attenuates Amyloid Toxicity by Downregulating its Endocytosis and Improves Cognitive Impairment[J]. JOURNAL OF ALZHEIMERS DISEASE,2012. |
| APA | Xiaqin Sun.,Xiaolu Meng.,Jie Zhang.,Yonghui Li.,Liping Wang.,...&Yan Zhang.(2012).GABA Attenuates Amyloid Toxicity by Downregulating its Endocytosis and Improves Cognitive Impairment.JOURNAL OF ALZHEIMERS DISEASE. |
| MLA | Xiaqin Sun,et al."GABA Attenuates Amyloid Toxicity by Downregulating its Endocytosis and Improves Cognitive Impairment".JOURNAL OF ALZHEIMERS DISEASE (2012). |
入库方式： OAI收割
来源：深圳先进技术研究院
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