Effects of tetracyclines on bones: an ambiguous question needs to be clarified
文献类型：期刊论文
| 作者 | Wenxiang Cheng; Ye Yue; Wenbin Fan; Yiping Hu; Xinluan Wang; Xiaohua Pan; Xiaoxiao Zhou; Ling Qin; Peng Zhang |
| 刊名 | PHARMAZIE
 |
| 出版日期 | 2012 |
| 英文摘要 | Tetracyclines have been widely used in bone histomorphometry to label new bone formation and apposition rate. However, most studies of tetracyclines have also shown their strong inhibitory action on osteoclasts and their effects on osteoblast activities as well. To even obtain the in-depth understanding on this issue, we have reviewed related studies in "Pubmed" by searching the keywords "tetracyclines and osteoclast", "tetracyclines and osteoblast", which retrieved 118 and 162 related documents, respectively. Among these papers, some described the application of tetracyclines as fluorescent marker in bone histomorphometry, while others discussed their role in protection of bone metabolism partly through inhibiting osteoclastogenesis or bone resorption and through enhancing osteogenesis. Based on the above mentioned, it seems that tetracyclines used as bone labeling markers may affect the results of bone histomorphometry to some extent. To even confirm the effect of tetracyclines on bones cells (osteoblast, osteoclast) and in vivo bone remodeling, related research work has been performed in our research team which indicated quite different results in vivo and in vitro. Therefore, the influence of tetracyclines on bones may differ in terms of different conditions which need to be further elucidated. |
| 收录类别 | SCI |
| 原文出处 | http://docserver.ingentaconnect.com/deliver/connect/govi/00317144/v67n5/s19.pdf?expires=1433259529&id=81959074&titleid=75007325&accname=University+Town+Library+of+Shenzhen&checksum=FF3E5C73BA844859878935B3481DADDD |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4019]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | PHARMAZIE |
| 推荐引用方式 GB/T 7714 | Wenxiang Cheng,Ye Yue,Wenbin Fan,et al. Effects of tetracyclines on bones: an ambiguous question needs to be clarified[J]. PHARMAZIE,2012. |
| APA | Wenxiang Cheng.,Ye Yue.,Wenbin Fan.,Yiping Hu.,Xinluan Wang.,...&Peng Zhang.(2012).Effects of tetracyclines on bones: an ambiguous question needs to be clarified.PHARMAZIE. |
| MLA | Wenxiang Cheng,et al."Effects of tetracyclines on bones: an ambiguous question needs to be clarified".PHARMAZIE (2012). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。