Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice
文献类型：期刊论文
| 作者 | Hui-Juan Cao; Rui-Rong Tan; Rong-Rong He; Lu-Ping Tang; Xin-Luan Wang; Nan Yao; Wen-Jun Duan; Yuan-Ao Hu; Xin-Sheng Yao; Hiroshi Kurihara |
| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2012 |
| 英文摘要 | Sarcandra glabra, as a type of “antipyretic-detoxicate drugs”, has always been widely used in traditional Chinese medicine (TCM). The Sarcandra glabra extract (SGE) is applied frequently as anti-inflammatory and anti-infectious drug in folk medicine. However, relative experiment data supporting this effective clinical consequence was limited. In order to mimic the physiological conditions of the susceptible population, we employed restraint stress mouse model to investigate the effect of SGE against influenza. Mice were infected with influenza virus three days after restraint, while SGE was orally administrated for 10 consecutive days. Body weight, morbidity, and mortality were recorded daily. Histopathologic changes, susceptibility genes expressions and inflammatory markers in lungs were determined. Our results showed that restraint stress significantly increased susceptibility and severity of influenza virus. However, oral administration of SGE could reduce morbidity, mortality and significantly prolonged survival time. The results further showed that SGE had a crucial effect on improving susceptibility markers levels to recover the balance of host defense system and inhibiting inflammatory cytokines levels through down-regulation of NF-B protein expression to ameliorate the lung injury. These data showed that SGE reduced the susceptibility and severity of influenza. |
| 收录类别 | SCI |
| 原文出处 | http://www.hindawi.com/journals/ecam/2012/236539/ |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4036]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE |
| 推荐引用方式 GB/T 7714 | Hui-Juan Cao,Rui-Rong Tan,Rong-Rong He,et al. Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012. |
| APA | Hui-Juan Cao.,Rui-Rong Tan.,Rong-Rong He.,Lu-Ping Tang.,Xin-Luan Wang.,...&Hiroshi Kurihara.(2012).Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. |
| MLA | Hui-Juan Cao,et al."Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012). |
入库方式： OAI收割
来源：深圳先进技术研究院
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