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Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery
文献类型：期刊论文
| 作者 | Qian Wan; Lisi Xie; Lin Gao; Zhiyong Wang; Xiang Nan; Hulong Lei; Xiaojing Long; Zhi-Ying Chen; Cheng-Yi He; Gang Liu |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2013 |
| 英文摘要 | As a versatile gene vector, minicircle DNA (mcDNA) has a great potential for gene therapy. However, some serious challenges remain, such as to effectively deliver mcDNA into targeted cells/tissues and to non-invasively monitor the delivery of the mcDNA. Superparamagnetic iron oxide (SPIO) nanoparticles have been extensively used for both drug/gene delivery and diagnosis. In this study, an MRI visible gene delivery system was developed with a core of SPIO nanocrystals and a shell of biodegradable stearic acid-modified low molecular weight polyethyleneimine (Stearic-LWPEI) via self-assembly. The Stearic-LWPEI-SPIO nanoparticles possess a controlled clustering structure, narrow size distribution and ultrasensitive imaging capacity. Furthermore, the nanoparticle can effectively bind with mcDNA and protect it from enzymatic degradation. In conclusion, the nanoparticle shows synergistic advantages in the effective transfection of mcDNA and non-invasive MRI of gene delivery. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.rsc.org/en/content/articlehtml/2013/nr/c2nr32438e |
| 语种 | 英语 |
| WOS记录号 | WOS:000313426200039 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4752]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | NANOSCALE |
| 推荐引用方式 GB/T 7714 | Qian Wan,Lisi Xie,Lin Gao,et al. Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery[J]. NANOSCALE,2013. |
| APA | Qian Wan.,Lisi Xie.,Lin Gao.,Zhiyong Wang.,Xiang Nan.,...&Bensheng Qiu.(2013).Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery.NANOSCALE. |
| MLA | Qian Wan,et al."Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery".NANOSCALE (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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