Effect of b-value in revealing postinfarct myocardial microstructural remodeling using MR diffusion tensor imaging
文献类型：期刊论文
| 作者 | Yin Wu; Chao Zou; Wei Liu; Weiqi Liao; Wei Yang; David A. Porter; Xin Liu; Ed X. Wu |
| 刊名 | MAGNETIC RESONANCE IMAGING
 |
| 出版日期 | 2013 |
| 英文摘要 | Nonmonoexponential diffusion behavior has been previously reported to exist in some biological tissues, making quantification of diffusion tensor imaging (DTI) indices dependent on diffusion sensitivity of b-value. This study aims to investigate the effect of b-value in revealing postinfarct myocardial microstructural remodeling in ex vivo hearts. DTI scans were performed on heart samples 1, 3, 5, and 7 days after infarction induction as well as intact controls with b-values of 500 to 2500 s/mm(2). DTI indices, including fractional anisotropy (FA), and mean and directional diffusivities, were measured in infarct, adjacent and remote regions with zero and each non-zero b-values respectively using conventional DTI analysis. Experimental results showed that these DTI indices decreased gradually with b-values in all regions and groups. Optimal b-values were found to vary with targeted DTI indices, and could strengthen DTI ability in revealing myocardium degradation with using conventional DTI approach. Specifically, FA showed the most sensitive detection of fiber integrity degradation at moderate b-values (approximate to 1500 to 2000 s/mm(2)), and the greatest ability of mean and directional diffusivities in monitoring diffusivity alteration occurred at relatively small b-values (<= 1500 s/mm(2)) during the necrotic and fibrotic phases. These findings may provide useful information for DTI protocol parameter optimization in assessing heart microstructures at other pathological or in vivo states in the future. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0730725X13000921 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4763]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | MAGNETIC RESONANCE IMAGING |
| 推荐引用方式 GB/T 7714 | Yin Wu,Chao Zou,Wei Liu,et al. Effect of b-value in revealing postinfarct myocardial microstructural remodeling using MR diffusion tensor imaging[J]. MAGNETIC RESONANCE IMAGING,2013. |
| APA | Yin Wu.,Chao Zou.,Wei Liu.,Weiqi Liao.,Wei Yang.,...&Ed X. Wu.(2013).Effect of b-value in revealing postinfarct myocardial microstructural remodeling using MR diffusion tensor imaging.MAGNETIC RESONANCE IMAGING. |
| MLA | Yin Wu,et al."Effect of b-value in revealing postinfarct myocardial microstructural remodeling using MR diffusion tensor imaging".MAGNETIC RESONANCE IMAGING (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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