Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers
文献类型：期刊论文
| 作者 | Fei Yan; Lu Li; Zhiting Deng; Qiaofeng Jin; Juanjuan Chen; Wei Yang; Chih-Kuang Yeh; Junru Wu; Robin Shandas; Xin Liu |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2013 |
| 英文摘要 | Liposome-microbubble complexes (LMC) have become a promising therapeutic carrier for ultrasound-triggered drug delivery to treat malignant tumors. However, the efficacy for ultrasound-assisted chemotherapy in vivo and the underlying mechanisms remain to be elucidated. Here, we investigated the feasibility of using paclitaxel-liposome-microbubble complexes (PLMC) as possible ultrasound (US)-triggered targeted chemotherapy against breast cancer. PTX-liposomes (PL) were conjugated to the microbubble (MB) surface through biotin-avidin linkage, increasing the drug-loading efficiency of MBs. The significant increased release of payloads from liposome-microbubble complexes was achieved upon US exposure. We used fluorescent quantum dots (QDs) as a model drug to show that released QDs were taken up by 4T1 breast cancer cells treated with QD-liposome-microbubble complexes (QLMC) and US, and uptake depended on the exposure time and intensity of insonication. We found that PLMC plus US inhibited tumor growth more effectively than PL plus US or PLMC without US, not only in vitro, but also in vivo. Histologically, the inhibition of tumor growth appeared to result from increased apoptosis and reduced angiogenesis in tumor xenografts. In addition, a significant increase of drug concentration in tumors was observed in comparison to treatment with non-conjugated PL or PLMC without US. The significant increase in an antitumor efficacy of PLMC plus US suggests their potential use as a new targeted US chemotherapeutic approach to inhibit breast cancer growth. |
| 收录类别 | SCI |
| 原文出处 | http://ac.els-cdn.com/S016836591200867X/1-s2.0-S016836591200867X-main.pdf?_tid=48be22e0-0857-11e5-b76d-00000aacb362&acdnat=1433160848_07291292eedba0178314171523245f6d |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4777]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | JOURNAL OF CONTROLLED RELEASE |
| 推荐引用方式 GB/T 7714 | Fei Yan,Lu Li,Zhiting Deng,et al. Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers[J]. JOURNAL OF CONTROLLED RELEASE,2013. |
| APA | Fei Yan.,Lu Li.,Zhiting Deng.,Qiaofeng Jin.,Juanjuan Chen.,...&Hairong Zheng.(2013).Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers.JOURNAL OF CONTROLLED RELEASE. |
| MLA | Fei Yan,et al."Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers".JOURNAL OF CONTROLLED RELEASE (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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