Gadolinium embedded iron oxide nanoclusters as T-1-T-2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery
文献类型：期刊论文
| 作者 | Xiaoyong Wang; Zijian Zhou; Zhiyong Wang; Yunxin Xue; Yun Zeng; Jinhao Gao; Lei Zhu; Xianzhong Zhang; Gang Liu; Xiaoyuan Chen |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2013 |
| 英文摘要 | This report illustrates a new strategy of designing a T1–T2 dual-modal magnetic resonance imaging (MRI)-visible vector for siRNA delivery and MRI. Hydrophobic gadolinium embedded iron oxide (GdIO) nanocrystals are self-assembled into nanoclusters in the water phase with the help of stearic acid modified low molecular weight polyethylenimine (stPEI). The resulting water-dispersible GdIO–stPEI nanoclusters possess good stability, monodispersity with narrow size distribution and competitive T1–T2 dual-modal MR imaging properties. The nanocomposite system is capable of binding and delivering siRNA for knockdown of a gene of interest while maintaining its magnetic properties and biocompatibility. This new gadolinium embedded iron oxide nanocluster provides an important platform for safe and efficient gene delivery with non-invasive T1–T2 dual-modal MRI monitoring capability. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.rsc.org/en/Content/ArticleLanding/2013/NR/c3nr02797j#!divAbstract |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4783]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | NANOSCALE |
| 推荐引用方式 GB/T 7714 | Xiaoyong Wang,Zijian Zhou,Zhiyong Wang,et al. Gadolinium embedded iron oxide nanoclusters as T-1-T-2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery[J]. NANOSCALE,2013. |
| APA | Xiaoyong Wang.,Zijian Zhou.,Zhiyong Wang.,Yunxin Xue.,Yun Zeng.,...&Xiaoyuan Chen.(2013).Gadolinium embedded iron oxide nanoclusters as T-1-T-2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery.NANOSCALE. |
| MLA | Xiaoyong Wang,et al."Gadolinium embedded iron oxide nanoclusters as T-1-T-2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery".NANOSCALE (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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