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Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis
文献类型：期刊论文
| 作者 | Zhao,Xuli; Yue,Ye; Cheng,Wengxiang; Li,Jingchao; Hu,Yiping; qin,Ling; Zhang,Peng |
| 刊名 | CURRENT DRUG TARGETS
 |
| 出版日期 | 2013 |
| 英文摘要 | The hypoxic microenvironment is a clinicopathological characteristic of many diseases, such as rheumatoid arthritis (RA). As a transcription factor activating the gene expression involved in processes such as cell metabolism and angiogenesis, hypoxia-inducible factor (HIF) has a central function in adaption to altered oxygen tension and even contributes to the progression of related diseases. In RA, HIF induces angiogenesis, cell migration, and cartilage destruction, inhibits the apoptosis of synovial cells and inflammatory cells and initiates glycolysis for energy supply by upregulating specific protein levels. HIF expression in RA can be regulated in both oxygen-dependent and independent fashions, leading to the aggravation of this disease. Therefore, HIF is one of the vital RA mediators. Based on the application of HIF-targeted drug research and development in tumors, HIF is a potential therapeutic target for treating RA. |
| 收录类别 | SCI |
| 原文出处 | http://chinesesites.library.ingentaconnect.com/content/ben/cdt/2013/00000014/00000006/art00010 |
| 语种 | 英语 |
| WOS记录号 | WOS:000318689000010 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4894]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | CURRENT DRUG TARGETS |
| 推荐引用方式 GB/T 7714 | Zhao,Xuli,Yue,Ye,Cheng,Wengxiang,et al. Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis[J]. CURRENT DRUG TARGETS,2013. |
| APA | Zhao,Xuli.,Yue,Ye.,Cheng,Wengxiang.,Li,Jingchao.,Hu,Yiping.,...&Zhang,Peng.(2013).Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis.CURRENT DRUG TARGETS. |
| MLA | Zhao,Xuli,et al."Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis".CURRENT DRUG TARGETS (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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