Exogenous phytoestrogenic molecule icaritin incorporated into a porous scaffold for enhancing bone defect repair
文献类型：期刊论文
| 作者 | Xin-Luan Wang; Xin-Hui Xie; Ge Zhang; Shi-Hui Chen; Dong Yao; Kai He; Xiao-Hong Wang; Xin-Sheng Yao; Yang Leng; kwok-Pui Fung |
| 刊名 | JOURNAL OF ORTHOPAEDIC RESEARCH
 |
| 出版日期 | 2013 |
| 英文摘要 | This study was designed to develop a bioactive scaffold to enhance bone defect repair in steroid-associated osteonecrosis (SAON). Icaritin, a metabolite of the herb Epimedium, has been identified as an angiogenic and osteogenic phytomolecule. Icaritin was homogenized into poly lactic-co-glycolic acid/tricalcium phosphate (PLGA/TCP) to form an icaritin-releasing porous composite scaffold (PLGA/TCP/icaritin) by fine-spinning technology. In vitro, high performance liquid chromatography was used to determine the release of icaritin during degradation of PLGA/TCP/icaritin. The osteogenic effects of PLGA/TCP/icaritin were evaluated using rat bone marrow mesenchymal stem cells (BMSCs). In vivo, the osteogenic effect of PLGA/TCP/icaritin was determined within a bone tunnel after core decompression in SAON rabbits and angiography within scaffolds was examined in rabbit muscle pouch model. In vitro study confirmed the sustainable release of icaritin from PLGA/TCP/icaritin with the bioactive scaffold promoting the proliferation and osteoblastic differentiation of rat BMSCs. In vivo study showed that PLGA/TCP/icaritin significantly promoted new bone formation within the bone defect after core decompression in SAON rabbits and enhanced neovascularization in the rabbit muscle pouch experiment. In conclusion, PLGA/TCP/icaritin is an innovative local delivery system that demonstrates sustainable release of osteogenic phytomolecule icaritin enhancing bone repair in an SAON rabbit model. The supplement of scaffold materials with bioactive phytomolecule(s) might improve treatment efficiency in challenging orthopedic conditions. |
| 收录类别 | SCI |
| 原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/jor.22188/pdf |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4910]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | JOURNAL OF ORTHOPAEDIC RESEARCH |
| 推荐引用方式 GB/T 7714 | Xin-Luan Wang,Xin-Hui Xie,Ge Zhang,et al. Exogenous phytoestrogenic molecule icaritin incorporated into a porous scaffold for enhancing bone defect repair[J]. JOURNAL OF ORTHOPAEDIC RESEARCH,2013. |
| APA | Xin-Luan Wang.,Xin-Hui Xie.,Ge Zhang.,Shi-Hui Chen.,Dong Yao.,...&Ling Qin.(2013).Exogenous phytoestrogenic molecule icaritin incorporated into a porous scaffold for enhancing bone defect repair.JOURNAL OF ORTHOPAEDIC RESEARCH. |
| MLA | Xin-Luan Wang,et al."Exogenous phytoestrogenic molecule icaritin incorporated into a porous scaffold for enhancing bone defect repair".JOURNAL OF ORTHOPAEDIC RESEARCH (2013). |
入库方式： OAI收割
来源：深圳先进技术研究院
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