Diurnal Microstructural Variations in Healthy Adult Brain Revealed by Diffusion Tensor Imaging
文献类型：期刊论文
| 作者 | Chunxiang Jiang; Lijuan Zhang; Chao Zou; Xiaojing Long; Xin Liu; Hairong Zheng; Weiqi Liao; Yanjun Diao |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2014 |
| 英文摘要 | Biorhythm is a fundamental property of human physiology. Changes in the extracellular space induced by cell swelling in response to the neural activity enable the in vivo characterization of cerebral microstructure by measuring the water diffusivity using diffusion tensor imaging (DTI). To study the diurnal microstructural alterations of human brain, fifteen right-handed healthy adult subjects were recruited for DTI studies in two repeated sessions (8: 30 AM and 8: 30 PM) within a 24-hour interval. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial (lambda(//)) and radial diffusivity (lambda(perpendicular to)) were compared pixel by pixel between the sessions for each subject. Significant increased morning measurements in FA, ADC, lambda(//) and lambda(perpendicular to) were seen in a wide range of brain areas involving frontal, parietal, temporal and occipital lobes. Prominent evening dominant lambda(perpendicular to) (18.58%) was detected in the right inferior temporal and ventral fusiform gyri. AM-PM variation of lambda(perpendicular to) was substantially left side hemisphere dominant (p<0.05), while no hemispheric preference was observed for the same analysis for ADC (p = 0.77), lambda(//) (p = 0.08) or FA (p = 0.25). The percentage change of ADC, lambda(//), lambda(perpendicular to), and FA were 1.59%, 2.15%, 1.20% and 2.84%, respectively, for brain areas without diurnal diffusivity contrast. Microstructural variations may function as the substrates of the phasic neural activities in correspondence to the environment adaptation in a light-dark cycle. This research provided a baseline for researches in neuroscience, sleep medicine, psychological and psychiatric disorders, and necessitates that diurnal effect should be taken into account in following up studies using diffusion tensor quantities. |
| 收录类别 | SCI |
| 原文出处 | http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0084822&representation=PDF |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5724]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | PLOS ONE |
| 推荐引用方式 GB/T 7714 | Chunxiang Jiang,Lijuan Zhang,Chao Zou,et al. Diurnal Microstructural Variations in Healthy Adult Brain Revealed by Diffusion Tensor Imaging[J]. PLOS ONE,2014. |
| APA | Chunxiang Jiang.,Lijuan Zhang.,Chao Zou.,Xiaojing Long.,Xin Liu.,...&Yanjun Diao.(2014).Diurnal Microstructural Variations in Healthy Adult Brain Revealed by Diffusion Tensor Imaging.PLOS ONE. |
| MLA | Chunxiang Jiang,et al."Diurnal Microstructural Variations in Healthy Adult Brain Revealed by Diffusion Tensor Imaging".PLOS ONE (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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