Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF
文献类型：期刊论文
| 作者 | Fan Yang; Yunhui Liu; Jie Tu; Jun Wan; Jie Zhang; Bifeng Wu; Shanping Chen; Jiawei Zhou; Yangling Mu; Liping Wang |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2014 |
| 英文摘要 | Astrocytes provide neuroprotective effects against degeneration of dopaminergic (DA) neurons and play a fundamental role in DA differentiation of neural stem cells. Here we show that light illumination of astrocytes expressing engineered channelrhodopsin variant (ChETA) can remarkably enhance the release of basic fibroblast growth factor (bFGF) and significantly promote the DA differentiation of human embryonic stem cells (hESCs) in vitro. Light activation of transplanted astrocytes in the substantia nigra (SN) also upregulates bFGF levels in vivo and promotes the regenerative effects of co-transplanted stem cells. Importantly, upregulation of bFGF levels, by specific light activation of endogenous astrocytes in the SN, enhances the DA differentiation of transplanted stem cells and promotes brain repair in a mouse model of Parkinson's disease (PD). Our study indicates that astrocyte-derived bFGF is required for regulation of DA differentiation of the stem cells and may provide a strategy targeting astrocytes for treatment of PD. |
| 收录类别 | SCI |
| 原文出处 | http://www.nature.com/ncomms/2014/141217/ncomms6627/pdf/ncomms6627.pdf |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5770]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | NATURE COMMUNICATIONS |
| 推荐引用方式 GB/T 7714 | Fan Yang,Yunhui Liu,Jie Tu,et al. Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF[J]. NATURE COMMUNICATIONS,2014. |
| APA | Fan Yang.,Yunhui Liu.,Jie Tu.,Jun Wan.,Jie Zhang.,...&Liping Wang.(2014).Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF.NATURE COMMUNICATIONS. |
| MLA | Fan Yang,et al."Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF".NATURE COMMUNICATIONS (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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