In vivo photoacoustic molecular imaging of breast carcinoma with folate receptor-targeted indocyanine green nanoprobes
文献类型：期刊论文
| 作者 | Huina Wang; Chengbo Liu; Xiaojing Gong; Dehong Hu; Riqiang Lin; Zonghai Sheng; Cuifang Zheng; Meng Yan; Jingqin Chen; Lintao Cai |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2014 |
| 英文摘要 | As an optical-acoustic hybrid imaging technology, photoacoustic imaging uniquely combines the advantages of rich optical contrast with high ultrasonic resolution in depth, opening up many new possibilities not attainable with conventional pure optical imaging technologies. To perform photoacoustic molecular imaging, optically absorbing exogenous contrast agents are needed to enhance the signals from specifically targeted disease activity. In this work, we designed and developed folate receptor targeted, indocyanine green dye doped poly(D, L-lactide-co-glycolide) lipid nanoparticles (FA-ICG-PLGA-lipid NPs) for molecular photoacoustic imaging of tumor. The fabricated FA-ICG-PLGA-lipid NPs exhibited good aqueous stability, a high folate-receptor targeting efficiency, and remarkable optical absorption in near-infrared wavelengths, providing excellent photoacoustic signals in vitro. Furthermore, after intravenous administration of FA-ICG-PLGA-lipid NPs, mice bearing MCF-7 breast carcinomas showed significantly enhanced photoacoustic signals in vivo in the tumor regions, compared with those using non-targeted ICG-PLGA-lipid NPs. Given the existing wide clinical use of ICG and PLGA, the developed FA-ICG-PLGA-lipid NPs, in conjunction with photoacoustic imaging technology, offer a great potential to be translated into the clinic for non-ionizing molecular imaging of breast cancer in vivo. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.rsc.org/en/content/articlehtml/2014/nr/c4nr03949a |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5781]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | NANOSCALE |
| 推荐引用方式 GB/T 7714 | Huina Wang,Chengbo Liu,Xiaojing Gong,et al. In vivo photoacoustic molecular imaging of breast carcinoma with folate receptor-targeted indocyanine green nanoprobes[J]. NANOSCALE,2014. |
| APA | Huina Wang.,Chengbo Liu.,Xiaojing Gong.,Dehong Hu.,Riqiang Lin.,...&Liang Song.(2014).In vivo photoacoustic molecular imaging of breast carcinoma with folate receptor-targeted indocyanine green nanoprobes.NANOSCALE. |
| MLA | Huina Wang,et al."In vivo photoacoustic molecular imaging of breast carcinoma with folate receptor-targeted indocyanine green nanoprobes".NANOSCALE (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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