Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo
文献类型：期刊论文
| 作者 | Zhenyuan Yang; Jianhua Chen; Junjie Yao; Riqiang Lin; Jing Meng; Chengbo Liu; Jinhua Yang; Xiang Li; Lihong Wang; Liang Song |
| 刊名 | OPTICS EXPRESS
 |
| 出版日期 | 2014 |
| 英文摘要 | Many diseases involve either the formation of new blood vessels (e.g., tumor angiogenesis) or the damage of existing ones (e.g., diabetic retinopathy) at the microcirculation level. Optical-resolution photoacoustic microscopy (OR-PAM), capable of imaging microvessels in 3D in vivo down to individual capillaries using endogenous contrast, has the potential to reveal microvascular information critical to the diagnosis and staging of microcirculation-related diseases. In this study, we have developed a dedicated microvascular quantification (MQ) algorithm for OR-PAM to automatically quantify multiple microvascular morphological parameters in parallel, including the vessel diameter distribution, the microvessel density, the vascular tortuosity, and the fractal dimension. The algorithm has been tested on in vivo OR-PAM images of a healthy mouse, demonstrating high accuracy for microvascular segmentation and quantification. The developed MQ algorithm for OR-PAM may greatly facilitate quantitative imaging of tumor angiogenesis and many other microcirculation related diseases in vivo. (C) 2014 Optical Society of America |
| 收录类别 | SCI |
| 原文出处 | https://www.osapublishing.org/oe/viewmedia.cfm?uri=oe-22-2-1500&seq=0 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5782]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | OPTICS EXPRESS |
| 推荐引用方式 GB/T 7714 | Zhenyuan Yang,Jianhua Chen,Junjie Yao,et al. Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo[J]. OPTICS EXPRESS,2014. |
| APA | Zhenyuan Yang.,Jianhua Chen.,Junjie Yao.,Riqiang Lin.,Jing Meng.,...&Liang Song.(2014).Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo.OPTICS EXPRESS. |
| MLA | Zhenyuan Yang,et al."Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo".OPTICS EXPRESS (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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