India ink incorporated multifunctional phase-transition nanaodroplets for photoacoustic/ultrasound dual-modality imaging and photoacoustic effect based tumor therapy
文献类型：期刊论文
| 作者 | Jia Jian; Chengbo Liu; Yuping Gong; Lei Su; Bin Zhang; Zhigang Wang; Dong wang; Yu Zhou; Fenfen Xu; Pan Li |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2014 |
| 英文摘要 | The in vivo applications of gas-core microbubbles have been limited by gas diffusion, rapid body clearance, and poor vascular permeability. To overcome these limitations, using a modified three-step emulsion process, we have developed a first-of-its-kind India ink incorporated optically- triggerable phase-transition perfluorocarbon nanodroplets (INDs) that can provide not only three types of contrast mechanisms-conventional/thermoelastic photoacoustic, phase-transition/nonlinear photoacoustic, and ultrasound imaging contrasts, but also a new avenue for photoacoustic effect mediated tumor therapy. Upon pulsed laser illumination above a relatively low energy threshold, liquid-gas phase transition of the INDs has been demonstrated both in vitro and in vivo, offering excellent contrasts for photoacoustic and ultrasound dual-modality imaging. With further increased laser energy, the nanodroplets have been shown to be capable of destructing cancer cells in vivo, presumably due to the photoacoustic effect induced shock-wave generation from the carbon particles of the incorporated India ink. The demonstrated results suggest that the developed multifunctional phase-transition nanodroplets have a great potential for many theranostic biomedical applications, including photoacoustic/ultrasound dual-modality molecular imaging and targeted, localized cancer therapy. |
| 收录类别 | SCI |
| 原文出处 | http://www.thno.org/v04p1026.pdf |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5785]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | THERANOSTICS |
| 推荐引用方式 GB/T 7714 | Jia Jian,Chengbo Liu,Yuping Gong,et al. India ink incorporated multifunctional phase-transition nanaodroplets for photoacoustic/ultrasound dual-modality imaging and photoacoustic effect based tumor therapy[J]. THERANOSTICS,2014. |
| APA | Jia Jian.,Chengbo Liu.,Yuping Gong.,Lei Su.,Bin Zhang.,...&Xiyuan Zhou.(2014).India ink incorporated multifunctional phase-transition nanaodroplets for photoacoustic/ultrasound dual-modality imaging and photoacoustic effect based tumor therapy.THERANOSTICS. |
| MLA | Jia Jian,et al."India ink incorporated multifunctional phase-transition nanaodroplets for photoacoustic/ultrasound dual-modality imaging and photoacoustic effect based tumor therapy".THERANOSTICS (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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