A comparative study of improvements Pre-filter methods bring on feature selection using microarray data
文献类型：期刊论文
| 作者 | Yingying Wang; Xiaomao Fan; Yunpeng Cai |
| 刊名 | Health Information Science and Systems
 |
| 出版日期 | 2014 |
| 英文摘要 | Background: Feature selection techniques have become an apparent need in biomarker discoveries with the development of microarray. However, the high dimensional nature of microarray made feature selection become time-consuming. To overcome such difficulties, filter data according to the background knowledge before applying feature selection techniques has become a hot topic in microarray analysis. Different methods may affect final results greatly, thus it is important to evaluate these pre-filter methods in a system way. Methods: In this paper, we compared the performance of statistical-based, biological-based pre-filter methods and the combination of them on microRNA-mRNA parallel expression profiles using L1 logistic regression as feature selection techniques. Four types of data were built for both microRNA and mRNA expression profiles. Results: Results showed that pre-filter methods could reduce the number of features greatly for both mRNA and microRNA expression datasets. The features selected after pre-filter procedures were shown to be significant in biological levels such as biology process and microRNA functions. Analyses of classification performance based on precision showed the pre-filter methods were necessary when the number of raw features was much bigger than that of samples. All the computing time was greatly shortened after pre-filter procedures. Conclusions: With similar or better classification improvements, less but biological significant features, pre-filter-based feature selection should be taken into consideration if researchers need fast results when facing complex computing problems in bioinformatics. |
| 收录类别 | 其他 |
| 原文出处 | http://www.hissjournal.com/content/pdf/2047-2501-2-7.pdf |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5799]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Health Information Science and Systems |
| 推荐引用方式 GB/T 7714 | Yingying Wang,Xiaomao Fan,Yunpeng Cai. A comparative study of improvements Pre-filter methods bring on feature selection using microarray data[J]. Health Information Science and Systems,2014. |
| APA | Yingying Wang,Xiaomao Fan,&Yunpeng Cai.(2014).A comparative study of improvements Pre-filter methods bring on feature selection using microarray data.Health Information Science and Systems. |
| MLA | Yingying Wang,et al."A comparative study of improvements Pre-filter methods bring on feature selection using microarray data".Health Information Science and Systems (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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