Beneficial effects of deferoxamine against astrocyte death induced by modified oxygen glucose deprivation
文献类型：期刊论文
| 作者 | Zhang Rui; Huang Qiaoying; Zou Liangyu; Cao Xu; Huang Heming; Chu Xiaofan |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2014 |
| 英文摘要 | The iron chelator deferoxamine (DFX) is efficacious in ameliorating hypoxic-ischemic brain injury. However, the effect of DFX worked in the ischemic and the mechanism is still unclear. Recent studies have shown that apoptosis and oncosis may be the pathways of cell death accountable for astrocytic death in the ischemic core. The effect of DFX on primary cultures of rat astrocytes later subjected to modified oxygen and glucose deprivation (OGD), which can mimic the circumstances in the ischemic core, was evaluated in this study. DFX pretreatment significantly suppressed cell death and ameliorated the cellular swelling ofastrocytes in the ischemic core, especially after 3 h of OGD. The release of lactate dehydrogenase (LDH) and the production of reactive oxygen species (ROS) were reduced by DFX pretreatment. DFX reduced the expression level of active caspase-3 and increased the expression level of HIF-1 alpha in astrocytesinduced by 3 h of OGD, but had no effect on aquaporin-4 (AQP4) expression. We conclude that DFX suppresses both apoptosis and oncosis in astrocytes in an in vitro model of the ischemic core. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0006899314010804 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5832]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | BRAIN RESEARCH |
| 推荐引用方式 GB/T 7714 | Zhang Rui,Huang Qiaoying,Zou Liangyu,et al. Beneficial effects of deferoxamine against astrocyte death induced by modified oxygen glucose deprivation[J]. BRAIN RESEARCH,2014. |
| APA | Zhang Rui,Huang Qiaoying,Zou Liangyu,Cao Xu,Huang Heming,&Chu Xiaofan.(2014).Beneficial effects of deferoxamine against astrocyte death induced by modified oxygen glucose deprivation.BRAIN RESEARCH. |
| MLA | Zhang Rui,et al."Beneficial effects of deferoxamine against astrocyte death induced by modified oxygen glucose deprivation".BRAIN RESEARCH (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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