Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats
文献类型：期刊论文
| 作者 | Suen Pui Kit; He Yi-Xin; Chow Dick Ho Kiu; Huang Le; Li Chaoyang; Ke Hua Zhu; Ominsky Michael S; Qin Ling |
| 刊名 | JOURNAL OF ORTHOPAEDIC RESEARCH
 |
| 出版日期 | 2014 |
| 英文摘要 | : Sclerostin is a negative regulator of bone formation. Sclerostin monoclonal antibody (Scl-Ab) treatment promoted bone healing in various animal models. To further evaluate the healing efficiency of Scl-Ab in osteotomy healing, we investigated the time course effects of systemic administration of Scl-Ab on fracture repair in rat femoral osteotomy model. A total of 120 six-month-old male SD rats were subjected to transverse osteotomy at the right femur mid-shaft. Rats were treated with vehicle or Scl-Ab treatment for 3, 6, or 9 weeks. Fracture healing was evaluated by radiography, micro-CT, micro-CT based angiography, 4-point bending mechanical test and histological assessment. Scl-Ab treatment resulted in significantly higher total mineralized callus volume fraction, BMD and enhanced neovascularization. Histologically, Scl-Ab treatment resulted in a significant reduction in fracture callus cartilage at week 6 and increase in bone volume at week 9, associated with a greater proportion of newly formed bone area at week 6 and 9 by fluorescence microscopy. Mechanical testing showed significantly higher ultimate load in Scl-Ab treatment group at week 6 and 9. This study has demonstrated that Scl-Ab treatment enhanced bone healing in a rat femoral osteotomy model, as reflected in increased bone formation, bone mass and bone strength. |
| 收录类别 | SCI |
| 原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/jor.22636/epdf |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5844]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | JOURNAL OF ORTHOPAEDIC RESEARCH |
| 推荐引用方式 GB/T 7714 | Suen Pui Kit,He Yi-Xin,Chow Dick Ho Kiu,et al. Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats[J]. JOURNAL OF ORTHOPAEDIC RESEARCH,2014. |
| APA | Suen Pui Kit.,He Yi-Xin.,Chow Dick Ho Kiu.,Huang Le.,Li Chaoyang.,...&Qin Ling.(2014).Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats.JOURNAL OF ORTHOPAEDIC RESEARCH. |
| MLA | Suen Pui Kit,et al."Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats".JOURNAL OF ORTHOPAEDIC RESEARCH (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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