Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells
文献类型：期刊论文
| 作者 | Wang Meng; Yu Teng; Zhu Chengyao; Sun Hui; Qiu Ying; Zhu Xia; Li Jinchao |
| 刊名 | NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
 |
| 出版日期 | 2014 |
| 英文摘要 | Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV), a natural polyphenolic compound, is known as a promising anti-cancer agent. In this study, we showed that RSV could inhibit the growth of B16 cells via induction of apoptosis. Moreover, our results showed for the first time that RSV induced autophagy in B16 cells, which might occur through ceramide accumulation and Akt/mTOR pathway inhibition. Inhibition of autophagy by an autophagic inhibitor 3-methyladenine (3-MA) or si-Beclin 1 enhanced RSV-induced cytotoxicity and apoptosis. Thus, autophagy inhibition represents a promising approach to improve the efficacy of RSV in the treatment of patients with melanoma. |
| 收录类别 | SCI |
| 原文出处 | http://www.tandfonline.com/doi/abs/10.1080/01635581.2013.878738#.VccvAtKl_bM |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5861]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL |
| 推荐引用方式 GB/T 7714 | Wang Meng,Yu Teng,Zhu Chengyao,et al. Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells[J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL,2014. |
| APA | Wang Meng.,Yu Teng.,Zhu Chengyao.,Sun Hui.,Qiu Ying.,...&Li Jinchao.(2014).Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells.NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL. |
| MLA | Wang Meng,et al."Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells".NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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