Numerical Study of the Mechanical Interaction Between the Carotid Atherosclerosis Plaque and the Blood Flow Field Distribution: A Geometric Assessment of the Plaque Vulnerability
文献类型：期刊论文
| 作者 | Xin Liu; Zhenzhou Li; Lina Pu; Zhifan Gao; WenHua Huang; Heye Zhang; and Yuan-Ting Zhang |
| 刊名 | Journal of Medical Imaging and Health Informatics
 |
| 出版日期 | 2015 |
| 英文摘要 | Background—The plaque geometry is playing an important role in thrombus formation by either the fibrous cap rupture causes the contact of necrotic lipid core with blood or high shear stress causes the activation of the platelets coagulation mechanism. This study introduced the location of the narrowest region of the stenosis as the only geometric variable effect on the stress–strain and hemodynamic distributions in the stenotic artery. Method and results—Five two-dimensional vascular models were constructed base on the ultrasound images of stenotic carotid artery. The vascular models are of the same degree (50%) of eccentric stenosis and blood flowplaque interaction simulations were performed separately. Our results indicated that the blood flow recirculation phenomenon is alleviated comparing the geometry with the narrowest region located proximally (PTG) to that of the geometry with the narrowest region located distally (DTG). The stress magnitude is elevated in PTG and the proximal shoulder of PTG became more vulnerable. The joint analysis of the stress–strain and hemodynamic distribution suggests that coagulation and aggregation of the blood particles are more likely to appear in DTG that promote the plaque progression and thrombosis when the underlying risk of rupture increase in PTG. Conclusion—The geometries of the plaque are diversified. The combination of multiplex characteristics could result in diverse contributions to the pathological and biological environment in the arteries. Therefore, specific feature investigation could provide detailed information that is not clear in the ultrasound examination that the narrowest region location could be a potential indicator to benefit in accurately assessing of the risk level in stroke screening procedure. |
| 收录类别 | SCI |
| 原文出处 | http://chinesesites.library.ingentaconnect.com/content/asp/jmihi/2015/00000005/00000001/art00024 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7038]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Journal of Medical Imaging and Health Informatics |
| 推荐引用方式 GB/T 7714 | Xin Liu,Zhenzhou Li,Lina Pu,et al. Numerical Study of the Mechanical Interaction Between the Carotid Atherosclerosis Plaque and the Blood Flow Field Distribution: A Geometric Assessment of the Plaque Vulnerability[J]. Journal of Medical Imaging and Health Informatics,2015. |
| APA | Xin Liu.,Zhenzhou Li.,Lina Pu.,Zhifan Gao.,WenHua Huang.,...&and Yuan-Ting Zhang.(2015).Numerical Study of the Mechanical Interaction Between the Carotid Atherosclerosis Plaque and the Blood Flow Field Distribution: A Geometric Assessment of the Plaque Vulnerability.Journal of Medical Imaging and Health Informatics. |
| MLA | Xin Liu,et al."Numerical Study of the Mechanical Interaction Between the Carotid Atherosclerosis Plaque and the Blood Flow Field Distribution: A Geometric Assessment of the Plaque Vulnerability".Journal of Medical Imaging and Health Informatics (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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