Evolving-pattern analysis of transient and long-term biomarkers for cancers: Hepatocellular carcinoma as a case
文献类型：期刊论文
| 作者 | Yingying Wang; Yunpeng Cai; Yingbo Miao |
| 刊名 | Interdisciplinary Sciences: Computational Life Sciences
 |
| 出版日期 | 2015 |
| 英文摘要 | Cancer is a complex disease arises from combinations of changes that occur over a period of time. With the development of bioinformatics, more and more biomarkers representing changes in cancers had been identified using gene expression profiles. However, biomarkers alone are quite limited in explaining the molecular processed occurred in the due process. In this paper, we develop an evolving-pattern analysis pipeline for in-depth studies of gene expression changes during different disease stages, choosing hepatocellular carcinoma (HCC) as a case. Enrichment analyses were performed on three levels: functional terms, validated genes, and regulation factors for all the biomarkers to find out their biological characters. Our results show that biomarkers with distinct evolving patterns exhibit quite different characteristics on functional and regulation levels. For the case of HCC, transient biomarkers are mostly annotated to metabolic processes, while long-term biomarkers are mostly annotated to regulation processes, with a larger number of enriched regulation factors. Furthermore, our pipeline reveals the important roles of microRNAs in various evolving patterns, which are known to be closely related to HCC. These results confirm that evolving-pattern analysis may provide a new sight for in-depth studies of biomarkers and diseases. |
| 收录类别 | SCI |
| 原文出处 | http://rd.springer.com/article/10.1007/s12539-014-0241-x |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7122]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Interdisciplinary Sciences: Computational Life Sciences |
| 推荐引用方式 GB/T 7714 | Yingying Wang,Yunpeng Cai,Yingbo Miao. Evolving-pattern analysis of transient and long-term biomarkers for cancers: Hepatocellular carcinoma as a case[J]. Interdisciplinary Sciences: Computational Life Sciences,2015. |
| APA | Yingying Wang,Yunpeng Cai,&Yingbo Miao.(2015).Evolving-pattern analysis of transient and long-term biomarkers for cancers: Hepatocellular carcinoma as a case.Interdisciplinary Sciences: Computational Life Sciences. |
| MLA | Yingying Wang,et al."Evolving-pattern analysis of transient and long-term biomarkers for cancers: Hepatocellular carcinoma as a case".Interdisciplinary Sciences: Computational Life Sciences (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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