jEcho: an Evolved Weight Vector to CHaracterize the Protein's Post-translational Modi¯cation mOtifs
文献类型：期刊论文
| 作者 | Miaomiao ZHAO; Zhao ZHANG; Guoqin MAI; Youxi LUO; Fengfeng ZHOU |
| 刊名 | Interdisciplinary Sciences: Computational Life Sciences
 |
| 出版日期 | 2015 |
| 英文摘要 | Abstract: Protein's post-translational modi¯cation (PTM) represents a major dynamic regulation of protein functions after the translation of polypeptide chains from mRNA molecule. Compared with the costly and labor intensive wet lab characterization of PTMs, the computer-based detection of PTM residues has been a ma- jor complementary technique in recent years. Previous studies demonstrated that the PTM-°anking positions convey di®erent contributions to the computational detection of PTM residue, but did not directly translate this observation into the in silico PTM prediction. We propose a weight vector to represent the variant con- tributions of the PTM °anking positions, and use an evolutionary algorithm to optimize the vector. Even a simple nearest neighbor algorithm with the incorporated optimal weight vector outperforms the currently avail- able algorithms. The algorithm is implemented as an easy-to-use computer program, jEcho version 1.0. The implementation language, Java, makes jEcho platform-independent and visually interactive. The predicted re- sults may be directly exported as publication-quality images or text ¯les. jEcho may be downloaded from http://www.healthinformaticslab.org/supp/. |
| 收录类别 | SCI |
| 原文出处 | http://link.springer.com/article/10.1007%2Fs12539-014-0253-6 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7124]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Interdisciplinary Sciences: Computational Life Sciences |
| 推荐引用方式 GB/T 7714 | Miaomiao ZHAO,Zhao ZHANG,Guoqin MAI,et al. jEcho: an Evolved Weight Vector to CHaracterize the Protein's Post-translational Modi¯cation mOtifs[J]. Interdisciplinary Sciences: Computational Life Sciences,2015. |
| APA | Miaomiao ZHAO,Zhao ZHANG,Guoqin MAI,Youxi LUO,&Fengfeng ZHOU.(2015).jEcho: an Evolved Weight Vector to CHaracterize the Protein's Post-translational Modi¯cation mOtifs.Interdisciplinary Sciences: Computational Life Sciences. |
| MLA | Miaomiao ZHAO,et al."jEcho: an Evolved Weight Vector to CHaracterize the Protein's Post-translational Modi¯cation mOtifs".Interdisciplinary Sciences: Computational Life Sciences (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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