Epsilon-caprolactone modified polyethylenimine for highly efficient antigen delivery and chemical exchange saturation transfer functional MR imaging
文献类型：期刊论文
| 作者 | Yan Tana; Lisi Xie; Zhiyong Wang; Na Zhang; Chao Zou; Zhi-ying Chen; Xin Liu; Jian Lu; Gang Liu; Hairong Zheng |
| 刊名 | Biomaterials
 |
| 出版日期 | 2015 |
| 英文摘要 | Serious challenges remain in immunotherapy, such as to effectively deliver antigens and non-invasively monitor biological processes. Therefore, we aim to design a useful nanocarrier for enhancing antigen-specific immune response and performing functional molecular imaging guided immunotherapy. To achieve this goal, ε-caprolactone modified polyethylenimine (PEI-CL) was prepared based on the ring-opening reaction. This novel macromolecule served as an optimal vehicle that efficiently bound ovalbumin (OVA) antigen forming a controlled nanostructure through electronic self-assembly and resulted in a substantially increased cellular uptake. In vivo, PEI-CL/OVA nanovaccine stimulated inflammatory cytokine production and promoted proliferation of OVA-specific T cells. Moreover, due to the unique chemical and physical properties, PEI-CL was demonstrated as a chemical exchange saturation transfer contrast agent for magnetic resonance imaging. In conclusion, the PEI-CL has synergistic advantages in the effective delivery of antigen and non-invasive imaging for tracking immunotherapeutic cells. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0142961215003270 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7130]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Biomaterials |
| 推荐引用方式 GB/T 7714 | Yan Tana,Lisi Xie,Zhiyong Wang,et al. Epsilon-caprolactone modified polyethylenimine for highly efficient antigen delivery and chemical exchange saturation transfer functional MR imaging[J]. Biomaterials,2015. |
| APA | Yan Tana.,Lisi Xie.,Zhiyong Wang.,Na Zhang.,Chao Zou.,...&Hairong Zheng.(2015).Epsilon-caprolactone modified polyethylenimine for highly efficient antigen delivery and chemical exchange saturation transfer functional MR imaging.Biomaterials. |
| MLA | Yan Tana,et al."Epsilon-caprolactone modified polyethylenimine for highly efficient antigen delivery and chemical exchange saturation transfer functional MR imaging".Biomaterials (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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