Fast and Accurate Pressure-Drop Prediction in Straightened Atherosclerotic Coronary Arteries
文献类型：期刊论文
| 作者 | Schrauwen Jelle T. C.; Koeze Dion J.; Wentzel Jolanda J.; van de Vosse Frans N.; van der Steen Anton F. W.; Gijsen Frank J. H. |
| 刊名 | ANNALS OF BIOMEDICAL ENGINEERING
 |
| 出版日期 | 2015 |
| 英文摘要 | Atherosclerotic disease progression in coronary arteries is influenced by wall shear stress. To compute patient-specific wall shear stress, computational fluid dynamics (CFD) is required. In this study we propose a method for computing the pressure-drop in regions proximal and distal to a plaque, which can serve as a boundary condition in CFD. As a first step towards exploring the proposed method we investigated ten straightened coronary arteries. First, the flow fields were calculated with CFD and velocity profiles were fitted on the results. Second, the Navier-Stokes equation was simplified and solved with the found velocity profiles to obtain a pressure-drop estimate (Delta p((1))). Next, Delta p((1)) was compared to the pressure-drop from CFD (Delta p(CFD)) as a validation step. Finally, the velocity profiles, and thus the pressure-drop were predicted based on geometry and flow, resulting in Delta p(geom). We found that Delta p(1) adequately estimated Delta p(CFD) with velocity profiles that have one free parameter beta. This beta was successfully related to geometry and flow, resulting in an excellent agreement between Delta p(CFD) and Delta p(geom): 3.9 +/- 4.9% difference at Re = 150. We showed that this method can quickly and accurately predict pressure-drop on the basis of geometry and flow in straightened coronary arteries that are mildly diseased. |
| 收录类别 | SCI |
| 原文出处 | www.ncbi.nlm.nih.gov/pubmed/25113232 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7143]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | ANNALS OF BIOMEDICAL ENGINEERING |
| 推荐引用方式 GB/T 7714 | Schrauwen Jelle T. C.,Koeze Dion J.,Wentzel Jolanda J.,et al. Fast and Accurate Pressure-Drop Prediction in Straightened Atherosclerotic Coronary Arteries[J]. ANNALS OF BIOMEDICAL ENGINEERING,2015. |
| APA | Schrauwen Jelle T. C.,Koeze Dion J.,Wentzel Jolanda J.,van de Vosse Frans N.,van der Steen Anton F. W.,&Gijsen Frank J. H..(2015).Fast and Accurate Pressure-Drop Prediction in Straightened Atherosclerotic Coronary Arteries.ANNALS OF BIOMEDICAL ENGINEERING. |
| MLA | Schrauwen Jelle T. C.,et al."Fast and Accurate Pressure-Drop Prediction in Straightened Atherosclerotic Coronary Arteries".ANNALS OF BIOMEDICAL ENGINEERING (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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