A Disposable Microfluidic Device for Controlled Drug Release from Thermal-Sensitive Liposomes by High Intensity Focused Ultrasound
文献类型：期刊论文
| 作者 | Long Meng; Zhiting Deng; Lili Niu; Fei Li; Fei Yan; Junru Wu; Feiyan Cai; Hairong Zheng |
| 刊名 | Theranostics
 |
| 出版日期 | 2015 |
| 英文摘要 | The drug release triggered thermally by high intensity focused ultrasound (HIFU) has been considered a promising drug delivery strategy due to its localized energy and non-invasive characters. However, the mechanism underlying the HIFU-mediated drug delivery remains unclear due to its complexity at the cellular level. In this paper, micro-HIFU (MHIFU) generated by a microfluidic device is introduced which is able to control the drugrelease from temperature-sensitive liposomes (TSL) and evaluate the thermal and mechanical effects of ultrasound on the cellular drug uptake and apoptosis. By simply adjusting the input electrical signal to the device, the temperature of sample can be maintained at 37 degrees C, 42 degrees C and 50 degrees C with the deviation of +/- 0.3 degrees C as desired. The flow cytometry results show that the drug delivery under MHIFU sonication leads toa significant increase in apoptosis compared to the drug release by incubation alone at elevated temperature of 42 degrees C. Furthermore, increased squamous and protruding structures on the surface membrane of cells were detected by atomic force microscopy (AFM) after MHIFU irradiation of TSL. We demonstrate that compared to the routine HIFU treatment, MHIFU enables monitoring of in situ interactions between the ultrasound and cell in real time. Furthermore, it can quantitatively analyze and characterize the alterations of the cell membrane as a function of the treatment time. |
| 收录类别 | SCI |
| 原文出处 | http://159.226.251.230/videoplayer/v05p1203.pdf?ich_u_r_i=d74ffb1f9ace2747260d52e3b37da198&ich_s_t_a_r_t=0&ich_e_n_d=0&ich_k_e_y=1545098921750963502428&ich_t_y_p_e=1&ich_d_i_s_k_i_d=3&ich_u_n_i_t=1 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7158]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Theranostics |
| 推荐引用方式 GB/T 7714 | Long Meng,Zhiting Deng,Lili Niu,et al. A Disposable Microfluidic Device for Controlled Drug Release from Thermal-Sensitive Liposomes by High Intensity Focused Ultrasound[J]. Theranostics,2015. |
| APA | Long Meng.,Zhiting Deng.,Lili Niu.,Fei Li.,Fei Yan.,...&Hairong Zheng.(2015).A Disposable Microfluidic Device for Controlled Drug Release from Thermal-Sensitive Liposomes by High Intensity Focused Ultrasound.Theranostics. |
| MLA | Long Meng,et al."A Disposable Microfluidic Device for Controlled Drug Release from Thermal-Sensitive Liposomes by High Intensity Focused Ultrasound".Theranostics (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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