Src blockage prevents destructive repair in steroid-associated osteonecrosis.
文献类型：期刊论文
| 作者 | Li-zhen Zheng; Hui-juan Cao; Tao Tang; Wei-Min Fu; Shi-hui Chen; Le Huang; Dick Ho Kiu Chow; Yi-xiang Wang; James Francis Griffith; Wei He |
| 刊名 | Bone
 |
| 出版日期 | 2015 |
| 英文摘要 | Destructive repair is the pathological feature of ONFH characterized with the elevated vascular permeability and persistent bone resorption, which is associated with higher VEGF expression, activated c-Src, and vascular leakage. Activated c-Src also participates in mediating endothelial permeability and osteoclasts activity. However, the molecular mechanism of the VEGF and c-Src contributing to the destructive repair process remains unknown. The purpose of this study is to delineate the role of VEGF and c-Src in triggering destructive repair of osteonecrosis in vitro, as well as to elucidate if VEGF mediating vascular permeability and osteoclastic bone resorption are Src dependent. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S8756328214005201 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7180]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Bone |
| 推荐引用方式 GB/T 7714 | Li-zhen Zheng,Hui-juan Cao,Tao Tang,et al. Src blockage prevents destructive repair in steroid-associated osteonecrosis.[J]. Bone,2015. |
| APA | Li-zhen Zheng.,Hui-juan Cao.,Tao Tang.,Wei-Min Fu.,Shi-hui Chen.,...&Ling Qin..(2015).Src blockage prevents destructive repair in steroid-associated osteonecrosis..Bone. |
| MLA | Li-zhen Zheng,et al."Src blockage prevents destructive repair in steroid-associated osteonecrosis.".Bone (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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