RIP1 modulates death receptor mediated apoptosis and autophagy in macrophages
文献类型：期刊论文
| 作者 | Zhenyu Yao; Peng Zhang; Hui Guo; Juan Shi; Shilian Li Yanxin Liu a, Dexian Zheng a,* |
| 刊名 | Molecular Oncology
 |
| 出版日期 | 2015 |
| 英文摘要 | Macrophages are responsible for defending against diverse pathogens and play a crucial role in the innate immune system. Macrophage's lifespan is determined by homeostatic balance between survival and apoptosis. Here we report that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers both apoptosis and autophagy in human U937 cells. Inhibition of autophagy facilitates TRAIL-induced apoptosis, suggesting that autophagy of macrophages protects against TRAIL-induced apoptosis. TRAIL treatment influences the expression of death receptors, indicating that TRAIL-induced apoptosis and autophagy are mediated by death receptors. RIP1 ubiquitination and expression regulate apoptosis and autophagy. Furthermore, expression and bioactivity of the p43/41-caspase-8 variant are critical to TRAIL-induced autophagy and apoptosis. Knockdown of RIP1 suppresses autophagy in macrophage. These data demonstrate that RIP1 is essential for the regulation of death receptor mediated autophagy and apoptosis. The results in this study contribute to understanding the regulation of autophagy and apoptosis in macrophages, and shed lights on death receptor-targeted therapy for cancer, inflammation and autoimmune diseases. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S1574789114002890 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7185]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Molecular Oncology |
| 推荐引用方式 GB/T 7714 | Zhenyu Yao,Peng Zhang,Hui Guo,et al. RIP1 modulates death receptor mediated apoptosis and autophagy in macrophages[J]. Molecular Oncology,2015. |
| APA | Zhenyu Yao,Peng Zhang,Hui Guo,Juan Shi,&Shilian Li Yanxin Liu a, Dexian Zheng a,*.(2015).RIP1 modulates death receptor mediated apoptosis and autophagy in macrophages.Molecular Oncology. |
| MLA | Zhenyu Yao,et al."RIP1 modulates death receptor mediated apoptosis and autophagy in macrophages".Molecular Oncology (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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